FCGR2B and BLK

Number of citations of the paper that reports this interaction (PMID 8756631)
8

Data Source:
HPRD (in vitro)

		FCGR2B	BLK
Gene Name		Fc fragment of IgG, low affinity IIb, receptor (CD32)	BLK proto-oncogene, Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding IgG Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Immune Response Signal Transduction Viral Process Regulation Of Immune Response	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response B Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 21297633)	Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Rheumatoid arthritis ( 21452313 19503088) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		11 interactors: APCS BLK C14orf1 CRP INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PTPN6	17 interactors: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS EGFR ERBB2 FCGR2A FCGR2B PLCG2 STAT3 UBE3A
Entrez ID		2213	640
HPRD ID		06849	01866
Ensembl ID		ENSG00000072694	ENSG00000136573
Uniprot IDs		P31994	E9PJX5 P51451 Q05D26
PDB IDs		2FCB
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Immune Response Regulation Of Immune System Process Response To Peptide Hormone Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Immune System Process Wound Healing Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Wounding Defense Response Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Response To Organonitrogen Compound Blood Coagulation Hemostasis Regulation Of Golgi Inheritance Cellular Response To Organonitrogen Compound Platelet Activation Response To Hormone Negative Regulation Of Myeloid Leukocyte Differentiation Caveolin-mediated Endocytosis Regulation Of Cellular Localization Cellular Response To Heat Regulation Of Body Fluid Levels Negative Regulation Of Monocyte Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phagocytosis Regulation Of Golgi Organization Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Proliferation Peptidyl-tyrosine Phosphorylation Endocytosis Response To Insulin Regulation Of MAP Kinase Activity	Regulation Of Immune Response Regulation Of Immune System Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Intracellular Signal Transduction Ovulation Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Antigen Receptor-mediated Signaling Pathway Immune System Process Cell Proliferation Intracellular Receptor Signaling Pathway Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Response To Lipid Ovarian Follicle Development Defense Response Central Nervous System Development Negative Regulation Of Cell Death Fc Receptor Signaling Pathway Ovulation Cycle Process Organ Development Rhythmic Process Interleukin-6-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Anoikis Positive Regulation Of Immune Response Female Gonad Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Development Of Primary Female Sexual Characteristics Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Response To Other Organism Response To External Stimulus Positive Regulation Of Transport Response To Biotic Stimulus Cellular Response To Organic Substance Cellular Response To Interleukin-6 B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f
Tagcloud (Intersection) ?