BLK and BCR

Number of citations of the paper that reports this interaction (PMID 8756631)
8

Data Source:
HPRD (in vivo)

		BLK	BCR
Gene Name		BLK proto-oncogene, Src family tyrosine kinase	breakpoint cluster region
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytosol Postsynaptic Density Membrane Cell Junction Protein Complex Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Rac GTPase Activator Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response B Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Response To Lipopolysaccharide Positive Regulation Of Rac GTPase Activity Inner Ear Morphogenesis Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Rho GTPase cycle Signaling by FGFR in disease Signaling by Rho GTPases Signaling by FGFR1 mutants Signaling by FGFR mutants Signaling by FGFR1 fusion mutants
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Rheumatoid arthritis ( 21452313 19503088) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470)
Protein-Protein Interactions		17 interactors: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS EGFR ERBB2 FCGR2A FCGR2B PLCG2 STAT3 UBE3A	44 interactors: ABL1 ABL2 APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 MLLT4 PIK3CG PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		640	613
HPRD ID		01866	01044
Ensembl ID		ENSG00000136573	ENSG00000186716
Uniprot IDs		E9PJX5 P51451 Q05D26	P11274
PDB IDs			1K1F 2AIN
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Immune System Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Intracellular Signal Transduction Ovulation Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Antigen Receptor-mediated Signaling Pathway Immune System Process Cell Proliferation Intracellular Receptor Signaling Pathway Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Response To Lipid Ovarian Follicle Development Defense Response Central Nervous System Development Negative Regulation Of Cell Death Fc Receptor Signaling Pathway Ovulation Cycle Process Organ Development Rhythmic Process Interleukin-6-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Anoikis Positive Regulation Of Immune Response Female Gonad Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Development Of Primary Female Sexual Characteristics Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Response To Other Organism Response To External Stimulus Positive Regulation Of Transport Response To Biotic Stimulus Cellular Response To Organic Substance Cellular Response To Interleukin-6 B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Signaling Cell Communication Intracellular Signal Transduction Positive Regulation Of Transport Regulation Of Cellular Localization Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Blood Coagulation Hemostasis Regulation Of Intracellular Transport Regulation Of Organelle Organization Regulation Of Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Innate Immune Response ERBB Signaling Pathway Immune Response Cellular Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Catalytic Activity Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Cellular Response To Stimulus Cellular Response To Peptide Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Wound Healing Regulation Of Protein Kinase Activity Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Response To Organic Substance Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Transferase Activity Fc Receptor Signaling Pathway
Tagcloud ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Difference) ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	absent agglutinin bm centers centroblasts centrocytes chimeric clusters fdc follicles follicular gc gcs germinal grafts hosts humoral lt ltbeta ltbetar lymphotoxin networks peanut pna radioresistant reciprocal reconstituted splenic tnfrp55
Tagcloud (Intersection) ?