BLK and BCAS2

Number of citations of the paper that reports this interaction (PMID 12406557)
1

Data Source:
HPRD (in vitro, two hybrid)

		BLK	BCAS2
Gene Name		BLK proto-oncogene, Src family tyrosine kinase	breast carcinoma amplified sequence 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Cell Junction
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response B Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Rheumatoid arthritis ( 21452313 19503088) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		17 interactors: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS EGFR ERBB2 FCGR2A FCGR2B PLCG2 STAT3 UBE3A	18 interactors: AIMP2 BLK CDC5L EP300 ESR1 ESR2 GOLGA2 HGS IKZF3 KRT40 PGR POT1 PPARG PRPF19 SF1 TCF4 TXNRD2 UBC
Entrez ID		640	10286
HPRD ID		01866	05777
Ensembl ID		ENSG00000136573	ENSG00000116752
Uniprot IDs		E9PJX5 P51451 Q05D26	B2R7W3 O75934
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Immune System Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Intracellular Signal Transduction Ovulation Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Antigen Receptor-mediated Signaling Pathway Immune System Process Cell Proliferation Intracellular Receptor Signaling Pathway Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Response To Lipid Ovarian Follicle Development Defense Response Central Nervous System Development Negative Regulation Of Cell Death Fc Receptor Signaling Pathway Ovulation Cycle Process Organ Development Rhythmic Process Interleukin-6-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Anoikis Positive Regulation Of Immune Response Female Gonad Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Development Of Primary Female Sexual Characteristics Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Response To Other Organism Response To External Stimulus Positive Regulation Of Transport Response To Biotic Stimulus Cellular Response To Organic Substance Cellular Response To Interleukin-6 B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Regulation Of Cell Proliferation Hormone-mediated Signaling Pathway Rhythmic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Steroid Hormone Stimulus RNA Metabolic Process Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Response To Steroid Hormone Ovulation Cycle Process Transcription, DNA-templated Tissue Development Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Female Gonad Development Biosynthetic Process Ovulation Cycle Transcription From RNA Polymerase II Promoter Development Of Primary Female Sexual Characteristics Regulation Of Transcription From RNA Polymerase II Promoter Sex Differentiation Cellular Nitrogen Compound Metabolic Process Cellular Response To Hormone Stimulus Response To Hormone Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Epithelium Development Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Organic Cyclic Compound Developmental Process Involved In Reproduction Cellular Response To Lipid Genitalia Development Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Telomerase Activity Regulation Of Gene Expression
Tagcloud ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	amplified ar assay carcinoma characterise characterised correlation degraded gst hsp90 immunohistochemical immunoprecipitation interacting lncap luciferase manners mtt p53 pca propose prostate proteasome pull regulator specimens stabilise stabilised suppressed upregulation
Tagcloud (Difference) ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	amplified ar assay carcinoma characterise characterised correlation degraded gst hsp90 immunohistochemical immunoprecipitation interacting lncap luciferase manners mtt p53 pca propose prostate proteasome pull regulator specimens stabilise stabilised suppressed upregulation
Tagcloud (Intersection) ?