BLK and UBE3A

Number of citations of the paper that reports this interaction (PMID 10449731)
40

Data Source:
HPRD (in vivo)

		BLK	UBE3A
Gene Name		BLK proto-oncogene, Src family tyrosine kinase	ubiquitin protein ligase E3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response B Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Rheumatoid arthritis ( 21452313 19503088) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		17 interactors: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS EGFR ERBB2 FCGR2A FCGR2B PLCG2 STAT3 UBE3A	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		640	7337
HPRD ID		01866	03375
Ensembl ID		ENSG00000136573	ENSG00000114062
Uniprot IDs		E9PJX5 P51451 Q05D26	Q05086 Q9BUI6 Q9H2G0
PDB IDs			1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Immune System Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Intracellular Signal Transduction Ovulation Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Antigen Receptor-mediated Signaling Pathway Immune System Process Cell Proliferation Intracellular Receptor Signaling Pathway Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Response To Lipid Ovarian Follicle Development Defense Response Central Nervous System Development Negative Regulation Of Cell Death Fc Receptor Signaling Pathway Ovulation Cycle Process Organ Development Rhythmic Process Interleukin-6-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Anoikis Positive Regulation Of Immune Response Female Gonad Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Development Of Primary Female Sexual Characteristics Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Response To Other Organism Response To External Stimulus Positive Regulation Of Transport Response To Biotic Stimulus Cellular Response To Organic Substance Cellular Response To Interleukin-6 B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?