BLK and CTR9

Number of citations of the paper that reports this interaction (PMID 8636124)
7

Data Source:
HPRD (in vitro)

		BLK	CTR9
Gene Name		BLK proto-oncogene, Src family tyrosine kinase	CTR9, Paf1/RNA polymerase II complex component
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	RNA Polymerase II Core Binding Protein Binding SH2 Domain Binding
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Differentiation Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response B Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated JAK-STAT Cascade Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Positive Regulation Of Histone H3-K79 Methylation
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 22446962) Rheumatoid arthritis ( 21452313 19503088) Systemic lupus erythematosus ( 23273568 23053960 18204098 21408207 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		17 interactors: BCAS2 BCL2 BCL2L1 BCR CBL CCDC33 CD79A CD79B CTR9 EFS EGFR ERBB2 FCGR2A FCGR2B PLCG2 STAT3 UBE3A	6 interactors: BLK CNTNAP2 HIST1H1C KMT2A SMAD9 TCEA1
Entrez ID		640	9646
HPRD ID		01866	06717
Ensembl ID		ENSG00000136573	ENSG00000198730
Uniprot IDs		E9PJX5 P51451 Q05D26	Q6PD62
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Regulation Of Immune System Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Intracellular Signal Transduction Ovulation Cycle Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Stimulus Antigen Receptor-mediated Signaling Pathway Immune System Process Cell Proliferation Intracellular Receptor Signaling Pathway Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Response To Lipid Ovarian Follicle Development Defense Response Central Nervous System Development Negative Regulation Of Cell Death Fc Receptor Signaling Pathway Ovulation Cycle Process Organ Development Rhythmic Process Interleukin-6-mediated Signaling Pathway B Cell Differentiation Negative Regulation Of Anoikis Positive Regulation Of Immune Response Female Gonad Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Development Of Primary Female Sexual Characteristics Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Response To Other Organism Response To External Stimulus Positive Regulation Of Transport Response To Biotic Stimulus Cellular Response To Organic Substance Cellular Response To Interleukin-6 B Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Release Of Cytochrome C From Mitochondria	Organ Development Positive Regulation Of Cellular Response To Drug Hemopoiesis Immune System Development Superior Temporal Gyrus Development Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Clustering Of Voltage-gated Potassium Channels System Development Regulation Of Response To Drug Multicellular Organismal Development Nucleosome Positioning Mullerian Duct Regression Anatomical Structure Development Protein Localization To Juxtaparanode Region Of Axon Neuronal Ion Channel Clustering Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Trimethylation Regulation Of Histone H3-K9 Acetylation Developmental Process Histone H4-K16 Acetylation Thalamus Development Positive Regulation Of Histone H3-K4 Methylation Vocalization Behavior Striatum Development Positive Regulation Of Macromolecule Biosynthetic Process Anatomical Structure Regression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone H3-K4 Methylation Subpallium Development Peptidyl-lysine Trimethylation
Tagcloud ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	antiparallel assembling assembly binds biochemical conserved coordinated detailed diverse elongation embryonic heterodimer histone identity leo1 maintenance modifications nucleosome octamer paf1 paf1c posttranscriptional recognition reveals scaffold shed sheet subcomplex tightly
Tagcloud (Difference) ?		appearance characteristic clonal clonality compartments composed constitutively developmental governing incompletely intermediate largely lineage lymphocyte lymphoid lymphomas phenotypes preb preferentially prob progenitor progenitors subsets susceptible thymic unexplored whose y495f	antiparallel assembling assembly binds biochemical conserved coordinated detailed diverse elongation embryonic heterodimer histone identity leo1 maintenance modifications nucleosome octamer paf1 paf1c posttranscriptional recognition reveals scaffold shed sheet subcomplex tightly
Tagcloud (Intersection) ?