F5 and ELANE

Number of citations of the paper that reports this interaction (PMID 9242537)
3

Data Source:
HPRD (in vitro)

		F5	ELANE
Gene Name		coagulation factor V (proaccelerin, labile factor)	elastase, neutrophil expressed
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Platelet Alpha Granule Lumen Vesicle	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Blood Circulation Platelet Activation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus
Pathways		Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Drotrecogin alfa Phenylmercury	Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 22672568)
Protein-Protein Interactions		10 interactors: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3	30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS
Entrez ID		2153	1991
HPRD ID		01964	00554
Ensembl ID			ENSG00000197561
Uniprot IDs		P12259	P08246
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Response To Stress Blood Coagulation Hemostasis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Leukocyte Migration Negative Regulation Of Coagulation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Wound Healing Acute Inflammatory Response Killing By Host Of Symbiont Cells Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Processing Proteolysis Regulation Of Protein Processing Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Peptidyl-amino Acid Modification Response To Stimulus Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Platelet Activation Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Locomotion Interaction With Symbiont Leukocyte Mediated Cytotoxicity Immune System Process Defense Response Regulation Of Proteolysis Acute-phase Response Response To Fungus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Movement Of Cell Or Subcellular Component Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Protein Metabolic Process Positive Regulation Of Cell Proliferation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation
Tagcloud ?		alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Difference) ?		alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy	absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype
Tagcloud (Intersection) ?