ELANE and CAMP

Number of citations of the paper that reports this interaction (PMID 11389039)
100

Data Source:
HPRD (in vitro)

		ELANE	CAMP
Gene Name		elastase, neutrophil expressed	cathelicidin antimicrobial peptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Surface Transcriptional Repressor Complex Secretory Granule Extracellular Vesicular Exosome	Extracellular Space Cell Wall Cytosol Specific Granule Cell Projection Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Transcription Corepressor Activity Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Collagen Catabolic Process Response To Lipopolysaccharide Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Leukocyte Migration Negative Regulation Of Chemotaxis Neutrophil Mediated Killing Of Fungus	Positive Regulation Of Protein Phosphorylation Innate Immune Response In Mucosa Positive Regulation Of Cell Proliferation Antibacterial Humoral Response Defense Response To Bacterium Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Growth Of Symbiont On Or Near Host Surface Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interaction With Host Killing By Host Of Symbiont Cells Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Phagosome Maturation
Pathways		Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix	Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis
Drugs		Pegfilgrastim Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 ONO-6818
Diseases
GWAS
Protein-Protein Interactions		30 interactors: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NL SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS	6 interactors: CTSG ELANE FPR2 LBP MAPK8 PRTN3
Entrez ID		1991	820
HPRD ID		00554	02722
Ensembl ID		ENSG00000197561	ENSG00000164047
Uniprot IDs		P08246	J3KNB4 P49913
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77	2FBS 2FBU 2FCG 2K6O 2LMF 4EYC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Wound Healing Regulation Of Proteolysis Response To Wounding Blood Coagulation Hemostasis Cell Activation Regulation Of Cellular Protein Metabolic Process Inflammatory Response Regulation Of Body Fluid Levels Negative Regulation Of Catalytic Activity Platelet Degranulation Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Defense Response Negative Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Platelet Activation Response To Stress Blood Circulation Regulation Of Wound Healing Regulation Of Catalytic Activity Response To External Stimulus Response To Stimulus Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Blood Coagulation Negative Regulation Of Plasminogen Activation Response To Other Organism Secretion By Cell Exocytosis Negative Regulation Of Fibrinolysis Positive Regulation Of Coagulation Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Wound Healing Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Regulation Of Chemotaxis Blood Vessel Morphogenesis Secretion Negative Regulation Of Coagulation	Negative Regulation Of Growth Of Symbiont In Host Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Killing By Host Of Symbiont Cells Response To Bacterium Defense Response Positive Regulation Of Immune Response Defense Response To Bacterium Response To Stress Neutrophil Mediated Immunity Response To Other Organism Response To Biotic Stimulus Killing Of Cells Of Other Organism Response To External Stimulus Defense Response To Fungus Negative Regulation Of Growth Response To Lipid Positive Regulation Of Interleukin-8 Production Regulation Of Immune Response Interaction With Symbiont Leukocyte Mediated Cytotoxicity Positive Regulation Of Immune System Process Immune System Process Response To Fungus Regulation Of Chemokine Production Collagen Catabolic Process Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Immune Response Regulation Of Immune System Process Acute Inflammatory Response Collagen Metabolic Process Toll-like Receptor 4 Signaling Pathway Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Toll-like Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Regulation Of Growth Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To UV Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Regulation Of Chemotaxis Activation Of Innate Immune Response
Tagcloud ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	2cl adh admittance antidiuretic ascending augment basolateral basolaterally bilayers channels cl clc conductance ctal cytosolic excised faces gate gated gating k1 ka microperfused mtal pka po rbclc rises thick threefold
Tagcloud (Difference) ?		absent anomalies congenital deceased describes eight eleven ethnic far g6pc3 gfi hax1 heterozygous homozygous inherited iran israel israeli kindreds myelogenous neutropenia none registry responding retrieved scn sequenced sweden wildtype	2cl adh admittance antidiuretic ascending augment basolateral basolaterally bilayers channels cl clc conductance ctal cytosolic excised faces gate gated gating k1 ka microperfused mtal pka po rbclc rises thick threefold
Tagcloud (Intersection) ?