F5

Gene Name		coagulation factor V (proaccelerin, labile factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Platelet Alpha Granule Lumen Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Blood Circulation Platelet Activation
Pathways		Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Drotrecogin alfa Phenylmercury
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 22672568)
Protein-protein Interactions		10 interactors: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3
Entrez ID		2153
HPRD ID		01964
Ensembl ID
Uniprot IDs		P12259
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Response To Stress Blood Coagulation Hemostasis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Leukocyte Migration Negative Regulation Of Coagulation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Wound Healing Acute Inflammatory Response Killing By Host Of Symbiont Cells Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Processing Proteolysis Regulation Of Protein Processing Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Peptidyl-amino Acid Modification Response To Stimulus Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Platelet Activation Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Locomotion Interaction With Symbiont Leukocyte Mediated Cytotoxicity Immune System Process Defense Response Regulation Of Proteolysis Acute-phase Response Response To Fungus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Movement Of Cell Or Subcellular Component Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Protein Metabolic Process Positive Regulation Of Cell Proliferation
Tagcloud ?		alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy