F5 and SERPINA3

Number of citations of the paper that reports this interaction (PMID 8216224)
5

Data Source:
HPRD (in vitro)

		F5	SERPINA3
Gene Name		coagulation factor V (proaccelerin, labile factor)	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Platelet Alpha Granule Lumen Vesicle	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Platelet Degranulation Proteolysis Blood Coagulation Blood Circulation Platelet Activation	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		Common Pathway Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Formation of Fibrin Clot (Clotting Cascade)
Drugs		Drotrecogin alfa Phenylmercury
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) D-dimer levels ( 21502573) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Uric acid levels ( 23703922) Venous thromboembolism ( 21980494 23650146 22672568)	Body mass index ( 23669352)
Protein-Protein Interactions		10 interactors: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3	25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		2153	12
HPRD ID		01964	00120
Ensembl ID			ENSG00000196136
Uniprot IDs		P12259	G3V5I3 P01011
PDB IDs		1CZS 1CZT 1CZV 1FV4 1Y61 3P6Z 3P70 3S9C	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA
Enriched GO Terms of Interacting Partners?		Peptidyl-glutamic Acid Carboxylation Post-translational Protein Modification Response To Stress Blood Coagulation Hemostasis Negative Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Leukocyte Migration Negative Regulation Of Coagulation Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Wound Healing Acute Inflammatory Response Killing By Host Of Symbiont Cells Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Blood Coagulation Negative Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Processing Proteolysis Regulation Of Protein Processing Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Peptidyl-amino Acid Modification Response To Stimulus Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Platelet Activation Fibrinolysis Negative Regulation Of Cellular Metabolic Process Regulation Of Growth Locomotion Interaction With Symbiont Leukocyte Mediated Cytotoxicity Immune System Process Defense Response Regulation Of Proteolysis Acute-phase Response Response To Fungus Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Movement Of Cell Or Subcellular Component Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Protein Metabolic Process Positive Regulation Of Cell Proliferation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response
Tagcloud ?		alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Difference) ?		alleviating average biofeedback case chemotherapy difference experiment f1 f10 f3 f4 given groups indicated intervention items others physical psychosomatic questionnaire reactions recruited relaxation scl scores seen serious training unhealthy	add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported
Tagcloud (Intersection) ?