SERPINA3 and DNAJC1

Number of citations of the paper that reports this interaction (PMID 14668352)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SERPINA3	DNAJC1
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	DnaJ (Hsp40) homolog, subfamily C, member 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleus Extracellular Vesicular Exosome Blood Microparticle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding	ATPase Activator Activity DNA Binding Chromatin Binding Protein Binding Chaperone Binding
	Biological Process	Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium	Regulation Of Translation Protein Folding Positive Regulation Of ATPase Activity Negative Regulation Of Proteolysis Regulation Of Protein Secretion
Pathways
Drugs
Diseases
GWAS		Body mass index ( 23669352)	Breast cancer ( 23535729) Ovarian cancer ( 23535730)
Protein-Protein Interactions		25 interactors: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1	4 interactors: ABHD16A HSPA5 ITIH4 SERPINA3
Entrez ID		12	64215
HPRD ID		00120	09922
Ensembl ID		ENSG00000196136	ENSG00000136770
Uniprot IDs		G3V5I3 P01011	Q96KC8
PDB IDs		1AS4 1QMN 2ACH 3CAA 3DLW 4CAA	2CQQ 2CQR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Proteolysis Protein Metabolic Process Killing By Host Of Symbiont Cells Defense Response Angiotensin Maturation Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Inflammatory Response Metabolic Process Regulation Of Protein Metabolic Process Neutrophil Mediated Immunity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Stress Killing Of Cells Of Other Organism Wound Healing Negative Regulation Of Growth Of Symbiont In Host Regulation Of Growth Defense Response To Fungus Central Nervous System Development Interaction With Symbiont Leukocyte Mediated Cytotoxicity Peptide Hormone Processing Response To Wounding Negative Regulation Of Cytokine Biosynthetic Process Response To Fungus Blood Coagulation Inflammatory Response Hemostasis Defense Response To Bacterium Negative Regulation Of Interleukin-12 Biosynthetic Process Interleukin-1 Beta Biosynthetic Process Neuromuscular Junction Development Response To Bacterium Regulation Of Angiogenesis Protein Processing Negative Regulation Of Growth Collagen Catabolic Process Facial Nucleus Development Leading Strand Elongation Factor XII Activation Synaptic Growth At Neuromuscular Junction Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Platelet Degranulation Regulation Of Body Fluid Levels Regulation Of Translation Acute Inflammatory Response	Acute-phase Response Acute Inflammatory Response Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity ER Overload Response Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Maintenance Of Protein Localization In Endoplasmic Reticulum Inflammatory Response Regulation Of Cellular Protein Metabolic Process Maintenance Of Gastrointestinal Epithelium Regulation Of Protein Metabolic Process Cellular Response To Antibiotic Epithelial Structure Maintenance Anatomical Structure Arrangement Regulation Of Catalytic Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Proteolysis Response To Cytokine Cerebellar Purkinje Cell Layer Development Negative Regulation Of Catalytic Activity Substantia Nigra Development Hyaluronan Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Toxin Transport Cellular Response To Interleukin-4 Negative Regulation Of Protein Metabolic Process Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Response To Antibiotic Response To Stress Cerebellar Cortex Development Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase
Tagcloud (Difference) ?		add assist backgroundin catb catg cathepsin cathepsins catk catl cats conclusionsa cystatin dilatative hf ht implantation inverted lvad mark mark6 mark7 methodsthe moment proteases question remodeling resultsthe submitted supported	10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase
Tagcloud (Intersection) ?