ERN1 and HSPA5

Number of citations of the paper that reports this interaction (PMID 12637535)
22

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ERN1	HSPA5
Gene Name		endoplasmic reticulum to nucleus signaling 1	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Cleavage Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest RNA Splicing Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Protein Metabolic Process MRNA Splicing, Via Endonucleolytic Cleavage And Ligation HAC1-type Intron Splice Site Recognition And Cleavage Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Peptidyl-serine Trans-autophosphorylation	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport
Pathways		IRE1alpha activates chaperones Unfolded Protein Response (UPR)	Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs			Antihemophilic Factor
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2 UBC	53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB
Entrez ID		2081	3309
HPRD ID		04943	00682
Ensembl ID		ENSG00000178607	ENSG00000044574
Uniprot IDs		O75460	P11021
PDB IDs		2HZ6 3P23	3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Protein Processing Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Neuron Death Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Signal Transduction Regulation Of Proteolysis Protein Metabolic Process Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Neuron Death Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Homodimerization Activity Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Binding	Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis
Tagcloud ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Difference) ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds
Tagcloud (Intersection) ?