ERN1 and TNFRSF1A

Number of citations of the paper that reports this interaction (PMID 16680093)
14

Data Source:
HPRD (in vivo)

		ERN1	TNFRSF1A
Gene Name		endoplasmic reticulum to nucleus signaling 1	tumor necrosis factor receptor superfamily, member 1A
Image
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Cleavage Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest RNA Splicing Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Protein Metabolic Process MRNA Splicing, Via Endonucleolytic Cleavage And Ligation HAC1-type Intron Splice Site Recognition And Cleavage Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Peptidyl-serine Trans-autophosphorylation	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway
Pathways		IRE1alpha activates chaperones Unfolded Protein Response (UPR)	TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		14 interactors: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2 UBC	60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		2081	7132
HPRD ID		04943	01861
Ensembl ID		ENSG00000178607	ENSG00000067182
Uniprot IDs		O75460	J9PH39 P19438
PDB IDs		2HZ6 3P23	1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Protein Processing Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Neuron Death Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Signal Transduction Regulation Of Proteolysis Protein Metabolic Process Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Neuron Death Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Homodimerization Activity Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Binding	Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Intersection) ?