ERN1 and TAOK3

Number of citations of the paper that reports this interaction (PMID 11278723)
99

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ERN1	TAOK3
Gene Name		endoplasmic reticulum to nucleus signaling 1	TAO kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Cytoplasm Plasma Membrane
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transferase Activity
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Cleavage Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest RNA Splicing Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Protein Metabolic Process MRNA Splicing, Via Endonucleolytic Cleavage And Ligation HAC1-type Intron Splice Site Recognition And Cleavage Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Peptidyl-serine Trans-autophosphorylation	MAPK Cascade Activation Of MAPKK Activity DNA Repair Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of JUN Kinase Activity Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		IRE1alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2 UBC	4 interactors: ATF7 ERN1 LRRK2 TRAF2
Entrez ID		2081	51347
HPRD ID		04943	11620
Ensembl ID		ENSG00000178607	ENSG00000135090
Uniprot IDs		O75460	Q9H2K8
PDB IDs		2HZ6 3P23
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Protein Processing Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Neuron Death Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Signal Transduction Regulation Of Proteolysis Protein Metabolic Process Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Neuron Death Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Homodimerization Activity Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Binding	Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Binding Positive Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Peptidyl-serine Phosphorylation Positive Regulation Of Binding Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Thioredoxin Peroxidase Activity By Peptidyl-threonine Phosphorylation HAC1-type Intron Splice Site Recognition And Cleavage MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Negative Regulation Of Peroxidase Activity Peptidyl-serine Trans-autophosphorylation Positive Regulation Of Phosphorylation Cellular Response To Inorganic Substance Positive Regulation Of Protein Modification Process Regulation Of Protein Binding Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Hydrolase Activity Cell Death Death Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Neuron Death Protein Autophosphorylation Regulation Of Protein Autoubiquitination Positive Regulation Of Dopamine Receptor Signaling Pathway Cellular Response To Dopamine Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Targeting To Mitochondrion Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Kidney Size Regulation Of Phosphorylation Regulation Of Binding Activation Of Protein Kinase Activity Cellular Response To Manganese Ion Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Intracellular Distribution Of Mitochondria Regulation Of Phosphorus Metabolic Process
Tagcloud ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7
Tagcloud (Difference) ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7
Tagcloud (Intersection) ?