HSPA5 and PCSK7

Number of citations of the paper that reports this interaction (PMID 10964928)
7

Data Source:
HPRD (in vitro, in vivo)

		HSPA5	PCSK7
Gene Name		heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	proprotein convertase subtilisin/kexin type 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Endoplasmic Reticulum Chaperone Complex Melanosome Extracellular Vesicular Exosome	Integral Component Of Golgi Membrane
	Molecular Function	Glycoprotein Binding Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Ribosome Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity
	Biological Process	Platelet Degranulation ER Overload Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Blood Coagulation Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Platelet Activation Positive Regulation Of Cell Migration ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Interleukin-4 Toxin Transport	Proteolysis Protein Processing Peptide Hormone Processing
Pathways		Platelet degranulation Antigen Presentation: Folding, assembly and peptide loading of class I MHC ATF6-alpha activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ Class I MHC mediated antigen processing & presentation Platelet activation, signaling and aggregation ATF6-alpha activates chaperones PERK regulates gene expression Unfolded Protein Response (UPR) Adaptive Immune System
Drugs		Antihemophilic Factor
Diseases
GWAS			Cardiovascular disease risk factors ( 21943158) Iron status biomarkers ( 21149283)
Protein-Protein Interactions		53 interactors: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HSPBP1 HTR3A ID2 IGHM KRT14 KRT18 KRT8 LCT LDLR METTL21A MTNR1A MTNR1B NDRG1 PAWR PCSK7 PRNP PSME3 RPN1 SEC61A1 SH3BP4 SIL1 SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBQLN4 VHL VWF YWHAB	6 interactors: CSDE1 HNRNPD HSPA5 PABPC1 PMCH SYNCRIP
Entrez ID		3309	9159
HPRD ID		00682	05339
Ensembl ID		ENSG00000044574
Uniprot IDs		P11021	Q16549
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP
Enriched GO Terms of Interacting Partners?		Response To Stimulus Cellular Response To Stimulus Apoptotic Signaling Pathway Response To Stress Blood Coagulation, Intrinsic Pathway Cell Activation Signal Transduction Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Signaling Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway Cell Death Death Cell Communication Platelet Activation Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Cellular Protein Metabolic Process Blood Coagulation Negative Regulation Of Cellular Metabolic Process Protein Oligomerization Hemostasis Response To External Stimulus Cellular Response To Organic Substance Protein Folding Regulation Of Lipid Metabolic Process Response To Organic Substance Response To Inorganic Substance Negative Regulation Of Protein Metabolic Process Platelet Degranulation Lipoprotein Catabolic Process Regulation Of Apoptotic Process Regulation Of Cholesterol Homeostasis Hepatocyte Apoptotic Process Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Receptor Signaling Pathway Axonogenesis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Viral Process Cellular Response To Stress Cell Development Anatomical Structure Morphogenesis	Regulation Of MRNA Stability Regulation Of RNA Stability MRNA Metabolic Process RNA Catabolic Process MRNA Stabilization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Regulation Of Translation RNA Splicing MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Translation Regulation Of Protein Folding In Endoplasmic Reticulum RNA Processing Catabolic Process Cerebellum Structural Organization Nuclear-transcribed MRNA Catabolic Process Regulation Of Cellular Protein Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Regulation Of Protein Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization Circadian Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process ER Overload Response Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Regulation Of MRNA 3'-end Processing Cellular Response To Antibiotic Anatomical Structure Arrangement Positive Regulation Of MRNA Catabolic Process Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Polyadenylation Cellular Response To Cytokine Stimulus Cerebellar Purkinje Cell Layer Development RNA Polyadenylation Substantia Nigra Development ER-associated Ubiquitin-dependent Protein Catabolic Process Toxin Transport Cellular Response To Interleukin-4 Response To Cytokine
Tagcloud ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage loci map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein loci locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Difference) ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 lies linkage map mmu2 nf1 occupy painting places probable rxra syntenic telomeric thirds	aric atherogenic atherosclerosis biracial chd close communities confidence dense discovered hazard hazards homogeneous incident insights interval ldl lipid lipoprotein locus lowest mellitus newly proportional quartile sdldl traits variants
Tagcloud (Intersection) ?		loci