ERN1 and SYVN1

Number of citations of the paper that reports this interaction (PMID 18369366)
14

Data Source:
HPRD (in vivo)

		ERN1	SYVN1
Gene Name		endoplasmic reticulum to nucleus signaling 1	synovial apoptosis inhibitor 1, synoviolin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding	Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Endothelial Cell Proliferation Transcription, DNA-templated Regulation Of Transcription, DNA-templated MRNA Cleavage Protein Phosphorylation Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest RNA Splicing Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of RNA Splicing Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Protein Metabolic Process MRNA Splicing, Via Endonucleolytic Cleavage And Ligation HAC1-type Intron Splice Site Recognition And Cleavage Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Peptidyl-serine Trans-autophosphorylation	In Utero Embryonic Development Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		IRE1alpha activates chaperones Unfolded Protein Response (UPR)	Hedgehog ligand biogenesis IRE1alpha activates chaperones Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: BAK1 BAX COPS5 HSP90AA1 HSPA5 MAP3K5 PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2 UBC	15 interactors: AMFR APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2J1 UBE2U UBE2Z USP7 VCP
Entrez ID		2081	84447
HPRD ID		04943	07618
Ensembl ID		ENSG00000178607	ENSG00000162298
Uniprot IDs		O75460	Q86TM6
PDB IDs		2HZ6 3P23
Enriched GO Terms of Interacting Partners?		Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Proteolysis Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Protein Processing Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Neuron Death Regulation Of Protein Binding Response To Endoplasmic Reticulum Stress Signal Transduction Regulation Of Proteolysis Protein Metabolic Process Regulation Of Protein Kinase Activity Signaling Positive Regulation Of Neuron Death Regulation Of Intracellular Signal Transduction Positive Regulation Of MAP Kinase Activity Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Protein Homodimerization Activity Cellular Response To DNA Damage Stimulus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Binding	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Apoptotic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Programmed Cell Death Protein Polyubiquitination Cell Death Death Cellular Macromolecule Catabolic Process ER-nucleus Signaling Pathway Cellular Response To Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Cellular Protein Modification Process Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Stress Neuron Death Proteolysis DNA Repair Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Cellular Response To Stimulus Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Catabolic Process Protein Metabolic Process Cellular Metabolic Process Response To Unfolded Protein Regulation Of Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Signal Transduction Protein K48-linked Ubiquitination Metabolic Process DNA Metabolic Process
Tagcloud ?		blockade correlates depends deubiquitinates e3 effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown ligase mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups
Tagcloud (Difference) ?		blockade correlates depends deubiquitinates effector endoplasmic endoribonuclease erni glioma homolog hypoxia hypoxic intensified knockdown mdm2 nuclei ofmdm2 peptidase perp repression reticulum suppression tp53 u87 ubiquitin ups7 usp7	array asd autism betulinic cortical div e16 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups
Tagcloud (Intersection) ?		e3 ligase