ERCC5 and NTHL1

Number of citations of the paper that reports this interaction (PMID 9927729)
24

Data Source:
HPRD (in vitro)

		ERCC5	NTHL1
Gene Name		excision repair cross-complementation group 5	nth endonuclease III-like 1 (E. coli)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Holo TFIIH Complex DNA-directed RNA Polymerase II, Holoenzyme Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Bubble DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding	Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endonuclease Activity Protein Binding DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Response To UV UV Protection Response To UV-C Negative Regulation Of Apoptotic Process	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER	Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS			Longevity ( 20834067)
Protein-Protein Interactions		8 interactors: ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 NTHL1 PCNA POLR2A	1 interactors: ERCC5
Entrez ID		2073	4913
HPRD ID		00595	04039
Ensembl ID		ENSG00000134899	ENSG00000065057
Uniprot IDs		P28715	E5KTI5 P78549
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation DNA Repair Transcription Elongation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Positive Regulation Of Viral Transcription DNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Stress Termination Of RNA Polymerase I Transcription DNA Catabolic Process Transcription Initiation From RNA Polymerase I Promoter Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Base-excision Repair DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Nucleotide-excision Repair, DNA Incision Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process MRNA Processing Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Viral Process Transcription, DNA-templated RNA Processing RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression	Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision Response To UV-C UV Protection Nucleotide-excision Repair, DNA Damage Removal Transcription-coupled Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Response To UV DNA Catabolic Process
Tagcloud ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease etc excision experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling repair seq	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex outside pkd1 pkd2 pkdts polycystic proved rab26 tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease excision experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling repair seq	aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation heterozygous immediately lies ligation mlpa monoallelic multiplex outside pkd1 pkd2 pkdts polycystic proved rab26 tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?		etc