ERCC5 and ERCC2

Number of citations of the paper that reports this interaction (PMID 8652557)
44

Data Source:
HPRD (in vitro)

		ERCC5	ERCC2
Gene Name		excision repair cross-complementation group 5	excision repair cross-complementation group 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Holo TFIIH Complex DNA-directed RNA Polymerase II, Holoenzyme Intermediate Filament Cytoskeleton	Core TFIIH Complex Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Spindle Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex MMXD Complex
	Molecular Function	Bubble DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding	DNA Binding ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity 5'-3' DNA Helicase Activity Metal Ion Binding Protein N-terminus Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Response To UV UV Protection Response To UV-C Negative Regulation Of Apoptotic Process	Nucleotide-excision Repair, DNA Damage Removal Response To Hypoxia In Utero Embryonic Development DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Apoptotic Process Response To Oxidative Stress Chromosome Segregation Aging Cell Proliferation UV Protection Post-embryonic Development Gene Expression Viral Process Spinal Cord Development Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Regulation Of Gene Expression, Epigenetic Erythrocyte Maturation Positive Regulation Of DNA Binding Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Hair Follicle Maturation Positive Regulation Of Viral Transcription Hematopoietic Stem Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cytosolic iron-sulfur cluster assembly RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Lung Cancer (DNA repair capacity) ( 23108145)
Protein-Protein Interactions		8 interactors: ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 NTHL1 PCNA POLR2A	14 interactors: AR CDK1 CDK7 ERCC3 ERCC5 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 RAD51 RAD52 TP53 TRIM25
Entrez ID		2073	2068
HPRD ID		00595	00530
Ensembl ID		ENSG00000134899	ENSG00000104884
Uniprot IDs		P28715	E7EVE9 P18074
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation DNA Repair Transcription Elongation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Positive Regulation Of Viral Transcription DNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Stress Termination Of RNA Polymerase I Transcription DNA Catabolic Process Transcription Initiation From RNA Polymerase I Promoter Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Base-excision Repair DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Nucleotide-excision Repair, DNA Incision Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process MRNA Processing Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Viral Process Transcription, DNA-templated RNA Processing RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression	Nucleotide-excision Repair Nucleotide-excision Repair, DNA Damage Removal DNA Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Cellular Response To Stress Positive Regulation Of Viral Transcription DNA Catabolic Process Response To Stress Regulation Of Viral Process Transcription Elongation From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation DNA-templated Transcription, Initiation Cellular Macromolecule Catabolic Process Viral Process Cellular Response To Stimulus Regulation Of Gene Expression, Epigenetic Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To UV Nitrogen Compound Metabolic Process Catabolic Process Positive Regulation Of Cellular Metabolic Process DNA Recombinase Assembly MRNA Processing Cellular Macromolecule Biosynthetic Process Response To Radiation Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease etc excision experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling repair seq	bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency excision innate lines methylguanine methyltransferase mgmt modifying nitrosourea nucleotide o6 poor repair resistance rich rodent sensitivity uv xpd
Tagcloud (Difference) ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease etc experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling seq	bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency innate lines methylguanine methyltransferase mgmt modifying nitrosourea nucleotide o6 poor resistance rich rodent sensitivity uv xpd
Tagcloud (Intersection) ?		excision repair