ERCC5 and GTF2H4

Number of citations of the paper that reports this interaction (PMID 16246722)
56

Data Source:
HPRD (in vivo)

		ERCC5	GTF2H4
Gene Name		excision repair cross-complementation group 5	general transcription factor IIH, polypeptide 4, 52kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor A Complex Holo TFIIH Complex DNA-directed RNA Polymerase II, Holoenzyme Intermediate Filament Cytoskeleton	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Bubble DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein N-terminus Binding	Sequence-specific DNA Binding Transcription Factor Activity ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal DNA Catabolic Process, Endonucleolytic DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Response To UV UV Protection Response To UV-C Negative Regulation Of Apoptotic Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process DNA Duplex Unwinding Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Transcription-coupled NER (TC-NER) Formation of incision complex in GG-NER Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in GG-NER Dual incision reaction in TC-NER	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Ulcerative colitis ( 20848476)
Protein-Protein Interactions		8 interactors: ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 NTHL1 PCNA POLR2A	10 interactors: ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 GTF2H3 POLR2A TBP TP53 XBP1P1
Entrez ID		2073	2968
HPRD ID		00595	03456
Ensembl ID		ENSG00000134899	ENSG00000213780
Uniprot IDs		P28715	Q92759
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation DNA Repair Transcription Elongation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Cellular Response To DNA Damage Stimulus Positive Regulation Of Viral Transcription DNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Stress Termination Of RNA Polymerase I Transcription DNA Catabolic Process Transcription Initiation From RNA Polymerase I Promoter Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Base-excision Repair DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Nucleotide-excision Repair, DNA Incision Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process MRNA Processing Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Stress Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Metabolic Process Viral Process Transcription, DNA-templated RNA Processing RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Viral Process Transcription From RNA Polymerase II Promoter Nucleotide-excision Repair 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process DNA Repair Gene Expression Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Incision Cellular Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Processing UV Protection Response To UV DNA Catabolic Process DNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease etc excision experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling repair seq
Tagcloud (Difference) ?		bisphenol bodies bpa characterize collectively cysteine differentially disruptor electrochemical endocrine endonuclease etc excision experiment focused harmful hek293 impacts implied list mcf microscopic morphology notably observation profiling repair seq
Tagcloud (Intersection) ?