NTHL1

Gene Name		nth endonuclease III-like 1 (E. coli)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endonuclease Activity Protein Binding DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination
Pathways		Base Excision Repair Depyrimidination Resolution of AP sites via the multiple-nucleotide patch replacement pathway Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected pyrimidine Removal of DNA patch containing abasic residue Base-Excision Repair, AP Site Formation Resolution of AP sites via the single-nucleotide replacement pathway Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Displacement of DNA glycosylase by APE1 Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS		Longevity ( 20834067)
Protein-protein Interactions		1 interactors: ERCC5
Entrez ID		4913
HPRD ID		04039
Ensembl ID		ENSG00000065057
Uniprot IDs		E5KTI5 P78549
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision Response To UV-C UV Protection Nucleotide-excision Repair, DNA Damage Removal Transcription-coupled Nucleotide-excision Repair DNA Catabolic Process, Endonucleolytic Nucleotide-excision Repair Response To UV DNA Catabolic Process
Tagcloud ?		aberrations adpkd array autosomal breakpoints cgh constitute contiguous deletions elucidation etc heterozygous immediately lies ligation mlpa monoallelic multiplex outside pkd1 pkd2 pkdts polycystic proved rab26 tsc tsc1 tsc2 tuberous