ERCC2

Gene Name		excision repair cross-complementation group 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Core TFIIH Complex Nucleus Nucleoplasm Holo TFIIH Complex Cytoplasm Spindle Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex MMXD Complex
	Molecular Function	DNA Binding ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity 5'-3' DNA Helicase Activity Metal Ion Binding Protein N-terminus Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Removal Response To Hypoxia In Utero Embryonic Development DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Apoptotic Process Response To Oxidative Stress Chromosome Segregation Aging Cell Proliferation UV Protection Post-embryonic Development Gene Expression Viral Process Spinal Cord Development Extracellular Matrix Organization Bone Mineralization Central Nervous System Myelin Formation DNA Duplex Unwinding Nucleotide-excision Repair, DNA Incision Multicellular Organism Growth Hair Cell Differentiation Embryonic Cleavage Regulation Of Gene Expression, Epigenetic Erythrocyte Maturation Positive Regulation Of DNA Binding Small Molecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Hair Follicle Maturation Positive Regulation Of Viral Transcription Hematopoietic Stem Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Cytosolic iron-sulfur cluster assembly RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Lung Cancer (DNA repair capacity) ( 23108145)
Protein-protein Interactions		14 interactors: AR CDK1 CDK7 ERCC3 ERCC5 GTF2H1 GTF2H2 GTF2H2C_2 GTF2H3 HERC5 RAD51 RAD52 TP53 TRIM25
Entrez ID		2068
HPRD ID		00530
Ensembl ID		ENSG00000104884
Uniprot IDs		E7EVE9 P18074
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Nucleotide-excision Repair, DNA Damage Removal DNA Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Cellular Response To Stress Positive Regulation Of Viral Transcription DNA Catabolic Process Response To Stress Regulation Of Viral Process Transcription Elongation From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation DNA-templated Transcription, Initiation Cellular Macromolecule Catabolic Process Viral Process Cellular Response To Stimulus Regulation Of Gene Expression, Epigenetic Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Stimulus Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To UV Nitrogen Compound Metabolic Process Catabolic Process Positive Regulation Of Cellular Metabolic Process DNA Recombinase Assembly MRNA Processing Cellular Macromolecule Biosynthetic Process Response To Radiation Macromolecule Biosynthetic Process Nucleotide-excision Repair, DNA Incision Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		bcnu bis cenu chloroethyl chloroethylnitrosourea complementing confirm correlations cytotoxicity deficiency excision innate lines methylguanine methyltransferase mgmt modifying nitrosourea nucleotide o6 poor repair resistance rich rodent sensitivity uv xpd