CC2D1B and SPP1

Number of citations of the paper that reports this interaction (PMID 22779921)
1

Data Source:
BioGRID (two hybrid)

		CC2D1B	SPP1
Gene Name		coiled-coil and C2 domain containing 1B	secreted phosphoprotein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription	Cytokine Activity Protein Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated	Osteoblast Differentiation Inflammatory Response Cell Adhesion Embryo Implantation Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Neutrophil Chemotaxis Biomineral Tissue Development Response To Vitamin D Positive Regulation Of Bone Resorption Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Pathways			Signaling by PDGF Integrin cell surface interactions Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		3 interactors: KLHL40 MDFI SPP1	88 interactors: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5F1 BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		200014	6696
HPRD ID		12393	01325
Ensembl ID		ENSG00000154222	ENSG00000118785
Uniprot IDs		Q5T0F9	B7Z351 P10451 Q3LGB0
PDB IDs			3CXD 3DSF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Placenta Development Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Skeletal Muscle Fiber Differentiation Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Reproductive Structure Development Reproductive System Development Positive Regulation Of Bone Resorption Organ Development Trophoblast Giant Cell Differentiation Regulation Of Axon Regeneration Cytoplasmic Sequestering Of Transcription Factor Dorsal/ventral Axis Specification Developmental Process Involved In Reproduction Cell Differentiation Cytoplasmic Sequestering Of Protein Positive Regulation Of Tissue Remodeling Decidualization Response To Vitamin D Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Bone Resorption Activation Of JUN Kinase Activity Negative Regulation Of DNA Binding Maternal Placenta Development System Development Regulation Of Bone Remodeling Negative Regulation Of Transcription Factor Import Into Nucleus Neutrophil Chemotaxis Neutrophil Migration Single Organism Reproductive Process Granulocyte Chemotaxis Myotube Differentiation Skeletal Muscle Cell Differentiation Negative Regulation Of Axonogenesis Multicellular Organismal Development Regulation Of Tissue Remodeling Positive Regulation Of JUN Kinase Activity Reproductive Process Anatomical Structure Development Negative Regulation Of Protein Import Into Nucleus Biomineral Tissue Development Embryo Implantation Regulation Of JUN Kinase Activity Maternal Process Involved In Female Pregnancy Negative Regulation Of Protein Localization To Nucleus Regulation Of DNA Binding JNK Cascade Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Developmental Growth	Wound Healing Blood Coagulation Hemostasis Movement Of Cell Or Subcellular Component Neuron Projection Development Response To Wounding Chemotaxis Locomotion Membrane Organization Cell Projection Organization Axon Development Neuron Development Developmental Process Regulation Of Body Fluid Levels Cellular Localization Extracellular Matrix Organization Regulation Of Proteasomal Protein Catabolic Process Extracellular Structure Organization Chemical Homeostasis Anatomical Structure Development Axon Guidance Axonogenesis System Development Leukocyte Migration Translational Initiation Viral Process Ion Homeostasis Regulation Of Cellular Process Nervous System Development Multicellular Organismal Development Cell Migration Neuron Differentiation Metal Ion Homeostasis Cell Morphogenesis Involved In Neuron Differentiation Translational Elongation Immune System Process Integrin-mediated Signaling Pathway Viral Life Cycle Anatomical Structure Morphogenesis Cell Motility Homeostatic Process Neuron Projection Morphogenesis Heterotypic Cell-cell Adhesion Response To Stress Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Development Regulation Of Protein Metabolic Process
Tagcloud ?			able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Difference) ?			able acquisition acts carcinomas cbx7 chemokine contributing counteracts decreases encoding fact hmga1b inducing interacting interferes involves malignant member modulation osteopontin played polycomb progressively relation repressive suppose take transcriptional whose
Tagcloud (Intersection) ?