DVL3 and DPPA2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL3	DPPA2
Gene Name		dishevelled segment polarity protein 3	developmental pluripotency associated 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm
	Molecular Function	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity	Chromatin Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Regulation Of Histone Methylation Lung-associated Mesenchyme Development Positive Regulation Of Stem Cell Proliferation
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Corneal astigmatism ( 23761726)
Protein-Protein Interactions		48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697	16 interactors: AP2M1 DPPA4 DVL2 DVL3 FXR2 MCM10 MOAP1 PBXIP1 PLOD3 SDCBP2 SETD5 SPOP U2AF2 VTA1 ZCCHC10 ZNF250
Entrez ID		1857	151871
HPRD ID		03222	13248
Ensembl ID		ENSG00000161202	ENSG00000163530
Uniprot IDs		Q92997	Q7Z7J5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly	Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Cochlea Development Outflow Tract Morphogenesis Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Intracellular Transport Canonical Wnt Signaling Pathway Cellular Localization Inner Ear Morphogenesis Convergent Extension Involved In Neural Plate Elongation Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Embryonic Development Protein Insertion Into Mitochondrial Membrane Basement Membrane Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Ear Morphogenesis Positive Regulation Of Stress-activated MAPK Cascade Non-canonical Wnt Signaling Pathway Via JNK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Convergent Extension Involved In Organogenesis Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Protein Localization Positive Regulation Of Wnt Signaling Pathway Regulation Of JNK Cascade Establishment Of Localization In Cell Positive Regulation Of Signal Transduction Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Neural Plate Morphogenesis Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Inner Ear Development Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Mitochondrial Outer Membrane Permeabilization Positive Regulation Of MAP Kinase Activity Endothelial Cell Morphogenesis Tube Development Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Ear Development
Tagcloud ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected	butyrate demethylation derivation efficiency enhances greatly insights ips karyotypes klf4 microarrays naturally nutritional permeable piggybac pluripotency pluripotent refractory remarkable reprogramming retroviral sickle somatic stimulation substitutes supplement transgene transposon vectors
Tagcloud (Difference) ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected	butyrate demethylation derivation efficiency enhances greatly insights ips karyotypes klf4 microarrays naturally nutritional permeable piggybac pluripotency pluripotent refractory remarkable reprogramming retroviral sickle somatic stimulation substitutes supplement transgene transposon vectors
Tagcloud (Intersection) ?