DVL3 and SYT6

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DVL3	SYT6
Gene Name		dishevelled segment polarity protein 3	synaptotagmin VI
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Cell Junction Synaptic Vesicle Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity	Transporter Activity Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Acrosomal Vesicle Exocytosis
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Breast cancer (prognosis) ( 23319801) Obesity-related traits ( 23251661)
Protein-Protein Interactions		48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697	15 interactors: APP BRCA1 DVL3 FXR2 GOLGA2 KCTD9 KRT40 MTUS2 NRXN1 PRKCB TNIP1 TRIM32 TSGA10 ZBTB43 ZBTB8A
Entrez ID		1857	148281
HPRD ID		03222	09654
Ensembl ID		ENSG00000161202	ENSG00000134207
Uniprot IDs		Q92997	I6L9C3 Q5T7P8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly	Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Cell Cycle Regulation Of Signaling Positive Regulation Of Histone H4-K20 Methylation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Positive Regulation Of Histone H4-K16 Acetylation Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Viral Process Neuromuscular Process Controlling Balance Synapse Assembly Synaptic Growth At Neuromuscular Junction Positive Regulation Of Histone H3-K9 Acetylation Histone H3-T6 Phosphorylation Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Regulation Of Synapse Structure Or Activity Regulation Of Nitrogen Compound Metabolic Process Response To Radiation Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Collateral Sprouting In Absence Of Injury Gephyrin Clustering Synaptic Vesicle Clustering Regulation Of Receptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Angiogenesis Response To Tumor Necrosis Factor Neuronal Signal Transduction Regulation Of Response To DNA Damage Stimulus Response To Abiotic Stimulus Neuromuscular Process Positive Regulation Of Cellular Protein Metabolic Process Learning Cellular Response To Indole-3-methanol Collateral Sprouting Axon Midline Choice Point Recognition Non-canonical Wnt Signaling Pathway Via JNK Cascade N-methyl-D-aspartate Receptor Clustering Vocal Learning Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Binding
Tagcloud ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?