DVL3 and TNFAIP8L1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DVL3	TNFAIP8L1
Gene Name		dishevelled segment polarity protein 3	tumor necrosis factor, alpha-induced protein 8-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm
	Molecular Function	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of TOR Signaling
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697	3 interactors: APP DVL3 PSME3
Entrez ID		1857	126282
HPRD ID		03222	11314
Ensembl ID		ENSG00000161202	ENSG00000185361
Uniprot IDs		Q92997	Q8WVP5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Peptidase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Synaptic Growth At Neuromuscular Junction Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Cycle Phase Transition Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Regulation Of Wnt Signaling Pathway Collateral Sprouting Axon Midline Choice Point Recognition Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Endopeptidase Activity Axon Choice Point Recognition Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Neuron Remodeling Regulation Of Cell Cycle Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Metabolic Process Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Outflow Tract Septum Morphogenesis Cellular Copper Ion Homeostasis Regulation Of Signaling Regulation Of Proteolysis Wnt Signaling Pathway, Planar Cell Polarity Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cochlea Morphogenesis Negative Regulation Of Catalytic Activity
Tagcloud ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected	autophagic autophagy choi competes copyright cul4 da discovered dopaminergic dysregulated e3 fbxw5 hydroxydopamine ligase mtor neurodegeneration ohda opposition os oxi pathogenic proteasomal protected reserved rights stabilizes tsc2 ubiquitination
Tagcloud (Difference) ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected	autophagic autophagy choi competes copyright cul4 da discovered dopaminergic dysregulated e3 fbxw5 hydroxydopamine ligase mtor neurodegeneration ohda opposition os oxi pathogenic proteasomal protected reserved rights stabilizes tsc2 ubiquitination
Tagcloud (Intersection) ?