DVL3 and CSNK1D

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		DVL3	CSNK1D
Gene Name		dishevelled segment polarity protein 3	casein kinase 1, delta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Golgi Apparatus Centrosome Spindle Cytosol Spindle Microtubule Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity	Glycoprotein Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Peptide Binding Tau-protein Kinase Activity Phosphoprotein Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation DNA Repair Protein Phosphorylation Endocytosis Organelle Organization Signal Transduction Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Spindle Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)
Protein-Protein Interactions		48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697	27 interactors: AKAP9 APP ARFGAP1 ATM BACE1 BRCA1 CDK5 CTNNB1 DVL1 DVL3 GJA1 HN1L KDR LURAP1 MAPT PER1 PER2 PER3 PPP1R14A PSEN2 SMAD2 SMAD3 SNAPIN SNCA TP53 TRIM9 YWHAZ
Entrez ID		1857	1453
HPRD ID		03222	02920
Ensembl ID		ENSG00000161202	ENSG00000141551
Uniprot IDs		Q92997	H7BYT1 P48730
PDB IDs			3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly	Regulation Of Cellular Component Organization Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Signaling Positive Regulation Of Protein Metabolic Process Apoptotic Process Cell Communication Programmed Cell Death Regulation Of Binding Cell Death Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Establishment Of Organelle Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Organelle Localization Regulation Of Cell Development Cell Development Negative Regulation Of Protein Metabolic Process Developmental Growth Cell-cell Signaling Regulation Of Organelle Organization Synapse Organization Regulation Of Cell Differentiation Embryonic Organ Development Growth Positive Regulation Of Metabolic Process Secretion By Cell Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Establishment Of Vesicle Localization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cellular Metabolic Process Vesicle Localization Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Synaptic Vesicle Transport Organelle Organization Negative Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?		achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?