DLG1 and KCNJ6

Number of citations of the paper that reports this interaction (PMID 10619846)
10

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		DLG1	KCNJ6
Gene Name		discs, large homolog 1 (Drosophila)	potassium channel, inwardly rectifying subfamily J, member 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Ion Transmembrane Transport
Pathways		Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Halothane
Diseases
GWAS			Electroencephalographic traits in alcoholism ( 22554406)
Protein-Protein Interactions		72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A	7 interactors: ADRB2 BIRC5 DLG1 DRD2 GABBR1 KCNJ3 KCNJ9
Entrez ID		1739	3763
HPRD ID		03007	02929
Ensembl ID		ENSG00000075711
Uniprot IDs		B4DF78 Q12959	P48051
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process	Synaptic Transmission Regulation Of Ion Transport Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Peristalsis Regulation Of Ion Transmembrane Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Potassium Ion Import Temperature Homeostasis Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Protein Kinase B Signaling Activation Of Protein Kinase Activity Negative Regulation Of Nucleotide Metabolic Process Negative Regulation Of Blood Pressure Smooth Muscle Contraction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Potassium Ion Transport Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Transferase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase B Signaling Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Type B Pancreatic Cell Proliferation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Positive Regulation Of Cell Division Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cell Communication Negative Regulation Of Dopamine Secretion Positive Regulation Of Exit From Mitosis
Tagcloud ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj3 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Difference) ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcna1 kcnd2 kcnj3 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant
Tagcloud (Intersection) ?