DLG1 and EZR

Number of citations of the paper that reports this interaction (PMID 11726633)
8

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		DLG1	EZR
Gene Name		discs, large homolog 1 (Drosophila)	ezrin
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways		Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		1739	7430
HPRD ID		03007	00475
Ensembl ID		ENSG00000075711	ENSG00000092820
Uniprot IDs		B4DF78 Q12959	P15311
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69	1NI2
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?