DLG1 and ATP2B2

Number of citations of the paper that reports this interaction (PMID 11274188)
36

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DLG1	ATP2B2
Gene Name		discs, large homolog 1 (Drosophila)	ATPase, Ca++ transporting, plasma membrane 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Cytoplasm Endoplasmic Reticulum Plasma Membrane Cilium Integral Component Of Membrane Apical Plasma Membrane Cell Junction Neuronal Cell Body Synapse Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Protein C-terminus Binding PDZ Domain Binding Calcium-dependent ATPase Activity Metal Ion Binding
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport	Transport Calcium Ion Transport Organelle Organization Lactation Blood Coagulation Sensory Perception Of Sound Locomotory Behavior Regulation Of Cell Size Cerebellar Purkinje Cell Differentiation Cerebellar Granule Cell Differentiation Neuron Differentiation Ion Transmembrane Transport Locomotion Serotonin Metabolic Process Otolith Mineralization CGMP Metabolic Process Regulation Of Synaptic Plasticity Synapse Organization Neuromuscular Process Controlling Balance Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Transmembrane Transport Auditory Receptor Cell Stereocilium Organization Calcium Ion Transmembrane Transport Cochlea Development
Pathways		Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS			Metabolite levels ( 19043545)
Protein-Protein Interactions		72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A	8 interactors: DLG1 DLG2 DLG4 ERBB2IP PDZD11 PRKCA SLC9A3R2 SNTA1
Entrez ID		1739	491
HPRD ID		03007	00160
Ensembl ID		ENSG00000075711	ENSG00000157087
Uniprot IDs		B4DF78 Q12959	Q01814 Q4J699 Q4LE63
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process	Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Receptor Clustering Nucleotide Phosphorylation Maintenance Of Apical/basal Cell Polarity Membrane Organization Protein Localization To Membrane Cell-cell Signaling Maintenance Of Cell Polarity Synaptic Transmission Cellular Protein Localization Cortical Actin Cytoskeleton Organization Asymmetric Protein Localization Cortical Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Protein Localization Regulation Of Sodium Ion Transport Negative Regulation Of Intracellular Signal Transduction Regulation Of Ion Transmembrane Transport Endomembrane System Organization Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Vasoconstriction By Circulating Norepinephrine Small Molecule Metabolic Process Cellular Localization Basal Protein Localization Histone H3-T6 Phosphorylation Cell-cell Junction Assembly Nucleotide Metabolic Process Chemotaxis Regulation Of Ion Transport Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Regulation Of Muscle Contraction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Synapse Organization Regulation Of Intracellular Signal Transduction Protein Localization To Basolateral Plasma Membrane T Cell Cytokine Production Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Behavior Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Grooming Behavior Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	ankrd2 arg autoprocessing bak calpain calpains capability cleavages controllers destabilizing eliminating favor glu glun2a grm1 ica512 igfbp2 lived mechanistically multitude nonprocessive oligomeric phe phosphatases pressures proteases rule underlies virtually
Tagcloud (Difference) ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	ankrd2 arg autoprocessing bak calpain calpains capability cleavages controllers destabilizing eliminating favor glu glun2a grm1 ica512 igfbp2 lived mechanistically multitude nonprocessive oligomeric phe phosphatases pressures proteases rule underlies virtually
Tagcloud (Intersection) ?