DLG1 and GPR124

Number of citations of the paper that reports this interaction (PMID 15021905)
5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DLG1	GPR124
Gene Name		discs, large homolog 1 (Drosophila)	G protein-coupled receptor 124
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding	G-protein Coupled Receptor Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport	Sprouting Angiogenesis G-protein Coupled Receptor Signaling Pathway Central Nervous System Development Positive Regulation Of Endothelial Cell Migration Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Chemotaxis Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways		Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A	1 interactors: DLG1
Entrez ID		1739	25960
HPRD ID		03007	08437
Ensembl ID		ENSG00000075711	ENSG00000020181
Uniprot IDs		B4DF78 Q12959	Q6YN44 Q96PE1
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process	T Cell Cytokine Production Hard Palate Development Receptor Localization To Synapse Immunological Synapse Formation Peristalsis Cytokine Production Involved In Immune Response Amyloid Precursor Protein Metabolic Process Membrane Raft Organization Endothelial Cell Proliferation Protein Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Smooth Muscle Tissue Development Positive Regulation Of Potassium Ion Transport T Cell Mediated Immunity Cortical Cytoskeleton Organization Negative Regulation Of Protein Kinase B Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Myelination Tight Junction Assembly Receptor Clustering Regulation Of Protein Localization To Plasma Membrane Smooth Muscle Contraction Nucleotide Phosphorylation Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of T Cell Proliferation Regulation Of Potassium Ion Transport Cell-cell Recognition Ureteric Bud Morphogenesis Regulation Of Sodium Ion Transport Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Apical Junction Assembly Nephron Morphogenesis Renal Tubule Morphogenesis Epithelial Cell Proliferation Negative Regulation Of T Cell Activation Lens Development In Camera-type Eye Renal Tubule Development Negative Regulation Of Leukocyte Cell-cell Adhesion Kidney Morphogenesis Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Homotypic Cell-cell Adhesion Palate Development Ureteric Bud Development
Tagcloud ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	3p atherogenesis causality cdkn1b csf3 dedifferentiation experimentation genemania gpcr gpr171 gpr176 gpr25 gpr32 gpr64 gprc5a hbp1 id2 il12 ingenuity intima moxldl nexus quiescent smc smcs themes transcriptomic zeb1
Tagcloud (Difference) ?		adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly	3p atherogenesis causality cdkn1b csf3 dedifferentiation experimentation genemania gpcr gpr171 gpr176 gpr25 gpr32 gpr64 gprc5a hbp1 id2 il12 ingenuity intima moxldl nexus quiescent smc smcs themes transcriptomic zeb1
Tagcloud (Intersection) ?