ADRB1 and SNTA1

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ADRB1	SNTA1
Gene Name		adrenoceptor beta 1	syntrophin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Receptor Signaling Protein Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Drug Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Dopamine Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Glycogen Catabolic Process Apoptotic Process Activation Of Adenylate Cyclase Activity Rho Protein Signal Transduction Aging Memory Response To Cold Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Heat Generation Positive Regulation Of Ras GTPase Activity Protein Localization To Organelle Negative Regulation Of Urine Volume Negative Regulation Of Multicellular Organism Growth Wound Healing Fear Response Positive Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Brown Fat Cell Differentiation Regulation Of Calcium Ion Transport Lipid Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cation Channel Activity	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Esmolol Betaxolol Isoetharine Metoprolol Atenolol Norepinephrine Timolol Phenylpropanolamine Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Dobutamine Pseudoephedrine Alprenolol Pindolol Salbutamol Isoproterenol Arbutamine Amiodarone Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Clenbuterol Oxprenolol Dronedarone Nebivolol Asenapine Droxidopa 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol
Diseases
GWAS		Birth weight ( 23202124) Blood pressure ( 21909110) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		16 interactors: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		153	6640
HPRD ID		00181	03009
Ensembl ID		ENSG00000043591	ENSG00000101400
Uniprot IDs		P08588	B4DX40 Q13424
PDB IDs		2LSQ
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Internalization Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Clustering Regulation Of Ion Transmembrane Transport Regulation Of Endocytosis Regulation Of Adrenergic Receptor Signaling Pathway Nucleotide Phosphorylation Signaling Regulation Of Cellular Component Organization Regulation Of Potassium Ion Transport Cell Communication Receptor Localization To Synapse Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Intracellular Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Receptor Metabolic Process Golgi Vesicle Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Catalytic Activity Cellular Localization Endocytosis Regulation Of Intracellular Signal Transduction Protein Localization To Synapse Positive Regulation Of Transport Positive Regulation Of Receptor Internalization Locomotion Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Histone Acetylation Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Organelle Organization Regulation Of Transmembrane Transporter Activity	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?