ADRB1 and DLGAP2

Number of citations of the paper that reports this interaction (PMID 11700307)
8

Data Source:
HPRD (in vitro)

		ADRB1	DLGAP2
Gene Name		adrenoceptor beta 1	discs, large (Drosophila) homolog-associated protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane	Neurofilament Postsynaptic Density Cell Junction Postsynaptic Membrane
	Molecular Function	Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Receptor Signaling Protein Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Drug Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Dopamine Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Protein Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Glycogen Catabolic Process Apoptotic Process Activation Of Adenylate Cyclase Activity Rho Protein Signal Transduction Aging Memory Response To Cold Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Heat Generation Positive Regulation Of Ras GTPase Activity Protein Localization To Organelle Negative Regulation Of Urine Volume Negative Regulation Of Multicellular Organism Growth Wound Healing Fear Response Positive Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Brown Fat Cell Differentiation Regulation Of Calcium Ion Transport Lipid Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cation Channel Activity	Neuron-neuron Synaptic Transmission
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Esmolol Betaxolol Isoetharine Metoprolol Atenolol Norepinephrine Timolol Phenylpropanolamine Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Dobutamine Pseudoephedrine Alprenolol Pindolol Salbutamol Isoproterenol Arbutamine Amiodarone Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Clenbuterol Oxprenolol Dronedarone Nebivolol Asenapine Droxidopa 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol
Diseases
GWAS		Birth weight ( 23202124) Blood pressure ( 21909110) Gaucher disease severity ( 22388998)	Menarche (age at onset) ( 23599027)
Protein-Protein Interactions		16 interactors: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	13 interactors: ADRB1 BZRAP1 DGCR6 DLG4 DLGAP1 GRK5 KRT40 KRTAP4-2 NLGN4X NOS1 SHANK2 SHANK3 SORBS2
Entrez ID		153	9228
HPRD ID		00181	09258
Ensembl ID		ENSG00000043591	ENSG00000198010
Uniprot IDs		P08588	Q9P1A6
PDB IDs		2LSQ
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Internalization Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Clustering Regulation Of Ion Transmembrane Transport Regulation Of Endocytosis Regulation Of Adrenergic Receptor Signaling Pathway Nucleotide Phosphorylation Signaling Regulation Of Cellular Component Organization Regulation Of Potassium Ion Transport Cell Communication Receptor Localization To Synapse Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Intracellular Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Receptor Metabolic Process Golgi Vesicle Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Catalytic Activity Cellular Localization Endocytosis Regulation Of Intracellular Signal Transduction Protein Localization To Synapse Positive Regulation Of Transport Positive Regulation Of Receptor Internalization Locomotion Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Histone Acetylation Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Organelle Organization Regulation Of Transmembrane Transporter Activity	Vocalization Behavior Social Behavior Regulation Of Postsynaptic Membrane Potential Synapse Assembly Learning Or Memory Synaptic Transmission Cognition Regulation Of Synaptic Transmission Learning Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synapse Organization Single-organism Behavior Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Behavior Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Membrane Potential Positive Regulation Of Ion Transmembrane Transport Dendritic Spine Morphogenesis Positive Regulation Of Synaptic Transmission Membrane Depolarization Memory Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Regulation Of Synaptic Plasticity Adult Behavior Exploration Behavior Postsynaptic Membrane Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Ion Transport Regulation Of The Force Of Heart Contraction Neurological System Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signaling Regulation Of Ion Transport Positive Regulation Of Membrane Potential Positive Regulation Of Lyase Activity Negative Regulation Of Blood Pressure Receptor Clustering Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Transporter Activity Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity
Tagcloud ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Difference) ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	bell bgh bio blots bromo cnp deoxyuridine dor fibrillary gfap gh glul glutamine grin2a gs haemoglobin hbb igf1 igf1r inactivity ionotropic modestly phosphodiesterase postsynaptic robustly sapap2 synapse synthetase tg
Tagcloud (Intersection) ?