ADRB1 and GRB2

Number of citations of the paper that reports this interaction (PMID 9843378)
16

Data Source:
HPRD (in vitro)

		ADRB1	GRB2
Gene Name		adrenoceptor beta 1	growth factor receptor-bound protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Vesicle Membrane Extracellular Vesicular Exosome Grb2-EGFR Complex
	Molecular Function	Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Receptor Signaling Protein Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Drug Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Dopamine Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding	Phosphotyrosine Binding SH3/SH2 Adaptor Activity Epidermal Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding Insulin Receptor Substrate Binding Poly(A) RNA Binding Ephrin Receptor Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Glycogen Catabolic Process Apoptotic Process Activation Of Adenylate Cyclase Activity Rho Protein Signal Transduction Aging Memory Response To Cold Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Heat Generation Positive Regulation Of Ras GTPase Activity Protein Localization To Organelle Negative Regulation Of Urine Volume Negative Regulation Of Multicellular Organism Growth Wound Healing Fear Response Positive Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Brown Fat Cell Differentiation Regulation Of Calcium Ion Transport Lipid Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cation Channel Activity	Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Cell-cell Signaling Axon Guidance Aging Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Viral Process Platelet Activation Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Receptor Internalization Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction In Response To DNA Damage Regulation Of MAPK Cascade Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Anatomical Structure Formation Involved In Morphogenesis Leukocyte Migration Protein Heterooligomerization Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Ionizing Radiation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Esmolol Betaxolol Isoetharine Metoprolol Atenolol Norepinephrine Timolol Phenylpropanolamine Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Dobutamine Pseudoephedrine Alprenolol Pindolol Salbutamol Isoproterenol Arbutamine Amiodarone Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Clenbuterol Oxprenolol Dronedarone Nebivolol Asenapine Droxidopa 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol	Pegademase bovine 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS		Birth weight ( 23202124) Blood pressure ( 21909110) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		16 interactors: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1	347 interactors: A2M ABI3 ABI3BP ABL1 ABL2 ADA ADAM12 ADAM15 ADRB1 ADRB2 AEBP1 AES AGT AHSG AJUBA ALAS2 ALOX5 AMBP ANXA2 AP4S1 APCS APOH APP ARHGAP17 ARHGAP32 ARHGAP9 ARHGEF5 ASAP1 ASAP2 ATP8 AXL B2M BCAR1 BCL2A1 BCR BLNK BPGM C1orf94 C21orf58 C21orf91 CALD1 CASC3 CASP2 CBL CBLB CBLC CCL5 CD164 CD19 CD22 CD247 CD28 CD2AP CD72 CDC42 CDKN1B CFH CHRM4 CHRND CKS2 CLU COPB1 COX6A1 CRK CRKL CSF1R CSF3R CSN2 CTAGE5 CTTN CUTA DAB2 DAG1 DCTN1 DCTN2 DDX17 DLGAP1 DNAJA3 DNAJB11 DNM1 DNM2 DOCK4 DPPA4 DRD3 DRD4 DTX1 ECHS1 EGF EGFR ELK1 ENO1 EP300 EPHA2 EPHB1 EPHB2 EPHB6 EPOR EPS15 EPS8 ERBB2 ERBB3 ERBB4 ERRFI1 ESD ESR1 ETV6 FABP1 FASLG FGFR1 FGFR3 FH FHOD1 FLT1 FLT3 FLT4 FN1 FRS2 FRS3 FTH1 FTL FYN GAB1 GAB2 GAB3 GAREM GC GHR GIT1 GPANK1 GRB7 GSTK1 H1F0 HCLS1 HELZ HIPK3 HNRNPC HNRNPK HOMEZ HP HRAS HSPA5 HTT IK IKZF3 IL2RB INCA1 INPP5D IRS1 IRS2 IRS4 ITGA2B ITGA6 ITGB4 ITIH4 ITK JAK1 JAK2 KDR KHDRBS1 KHDRBS2 KIAA1549L KIF3A KIT KPNA2 KRT8 LAT LAT2 LAX1 LCP2 LIME1 LMO2 LNX1 LY6G6F LZTS2 MAP1A MAP2 MAP3K1 MAP4K1 MAP4K3 MAP4K5 MAPK1 MAPK12 MAPK14 MAPK9 MED28 MERTK MET MICAL1 MLXIPL MS4A2 MSI2 MST1R MTA1 MTA3 MUC1 MYH11 MYH9 MYO18A NADK NAP1L5 NCKIPSD NCL ND4 NEU3 NFYB NGFR NIF3L1 NKD2 NPM1 NTRK1 NUTM2F OCRL PAG1 PAK1 PAK2 PAK4 PBXIP1 PDCD6IP PDE4D PDE6G PDGFRB PHACTR4 PHC2 PIK3AP1 PIK3C2B PIK3CG PIK3R1 PIK3R2 PLCG1 PNMA5 PNRC1 POLR1D POLR2A POMP PON2 PPP3CA PRAP1 PRKAB1 PRKAR1A PRNP PRR22 PRRC2A PTK2 PTK2B PTPN1 PTPN11 PTPN12 PTPN22 PTPN23 PTPN6 PTPRA PTPRC PTPRE PXN RALGPS1 RAPGEF1 RAPSN RASA1 RBBP6 RBM33 RBP4 REL REPS1 REPS2 RET RHOU RIF1 RNF10 RPS6KA1 SELL SF3B4 SH2B1 SH2B2 SH2B3 SH2D1A SH2D4A SH3BP2 SH3D19 SH3KBP1 SHANK3 SHB SHBG SHC1 SHC2 SHC3 SHC4 SHKBP1 SIGLEC7 SIT1 SKAP1 SLC1A2 SLX1A SNRNP200 SNTA1 SOCS1 SOCS7 SOS1 SOS2 SPRY1 SPRY2 SPTBN1 SRC SS18 STAMBP STK32C STRADB SYK SYN1 SYNCRIP SYNJ1 SYNJ2 SYP TCEAL8 TCERG1 TEK TF TFG TNFRSF1A TNK2 TOM1L1 TP53BP2 TP63 TRAT1 TRIM27 TSC2 TUB UBA1 UBA52 USP53 USP6NL USP8 VAV1 VAV2 VAV3 VIM WAS WASF1 WASF2 WASL WBP11 WDR1 WDR44 WIPF1 WIPF2 YLPM1 ZAP70 ZBTB7B
Entrez ID		153	2885
HPRD ID		00181	00150
Ensembl ID		ENSG00000043591	ENSG00000177885
Uniprot IDs		P08588	B0LPF3 P62993
PDB IDs		2LSQ	1AZE 1BM2 1BMB 1CJ1 1FHS 1FYR 1GCQ 1GFC 1GFD 1GHU 1GRI 1IO6 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 2VVK 2VWF 2W0Z 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O
Enriched GO Terms of Interacting Partners?		Regulation Of Receptor Internalization Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Clustering Regulation Of Ion Transmembrane Transport Regulation Of Endocytosis Regulation Of Adrenergic Receptor Signaling Pathway Nucleotide Phosphorylation Signaling Regulation Of Cellular Component Organization Regulation Of Potassium Ion Transport Cell Communication Receptor Localization To Synapse Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Intracellular Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Receptor Metabolic Process Golgi Vesicle Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Catalytic Activity Cellular Localization Endocytosis Regulation Of Intracellular Signal Transduction Protein Localization To Synapse Positive Regulation Of Transport Positive Regulation Of Receptor Internalization Locomotion Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Histone Acetylation Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Organelle Organization Regulation Of Transmembrane Transporter Activity	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Signal Transduction Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune System Process Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Catalytic Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Innate Immune Response Fc Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Response To Stress Immune Response Positive Regulation Of Kinase Activity Defense Response Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Substance Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Locomotion Developmental Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Protein Metabolic Process Response To Growth Factor Cellular Response To Organic Substance
Tagcloud ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?		alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2	actions adaptor antiapoptotic behavior believed chemotactic converting crkii crkl focused igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Intersection) ?