ADORA1 and GNAZ

Number of citations of the paper that reports this interaction (PMID 9166747)
1

Data Source:
HPRD (in vitro)

		ADORA1	GNAZ
Gene Name		adenosine A1 receptor	guanine nucleotide binding protein (G protein), alpha z polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Basolateral Plasma Membrane Axolemma Asymmetric Synapse Presynaptic Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Postsynaptic Membrane Presynaptic Active Zone	Nuclear Envelope Endoplasmic Reticulum Cytosol Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Adenosine Receptor Activity G-protein Coupled Receptor Binding Purine Nucleoside Binding Phospholipase C Activity Protein Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Binding Protein Heterodimerization Activity	GTPase Activity Signal Transducer Activity Receptor Signaling Protein Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Activation Of MAPKK Activity Temperature Homeostasis Response To Hypoxia Adenosine Receptor Signaling Pathway Regulation Of Respiratory Gaseous Exchange By Neurological System Process Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Leukocyte Migration Positive Regulation Of Peptide Secretion Regulation Of Glomerular Filtration Protein Targeting To Membrane Phagocytosis Inflammatory Response Signal Transduction Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Glutamate Secretion Lipid Catabolic Process Negative Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Nucleoside Transport Negative Regulation Of Neurotrophin Production Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Renal Sodium Excretion Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Apoptotic Process Positive Regulation Of Potassium Ion Transport Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Negative Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Regulation Of Synaptic Plasticity Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Negative Regulation Of Lipid Catabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cardiac Muscle Contraction Regulation Of Excitatory Postsynaptic Membrane Potential Relaxation Of Vascular Smooth Muscle Negative Regulation Of Mucus Secretion Apoptotic Signaling Pathway Negative Regulation Of Long Term Synaptic Depression	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by GPCR GPCR downstream signaling PLC beta mediated events G alpha (s) signalling events G-protein activation Opioid Signalling G alpha (z) signalling events G alpha (i) signalling events G-protein mediated events
Drugs		Caffeine Theophylline Adenosine Dyphylline Pentoxifylline Gabapentin Aminophylline Oxtriphylline Theobromine Defibrotide
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		11 interactors: ADA ATXN1L DRD1 EPB41L2 GNAI2 GNAO1 GNAS GNAZ GRM1 P2RY1 SNF8	15 interactors: ADORA1 APP DRD2 DRD5 EYA1 EYA2 NMT1 NUCB1 OPRD1 PRKCD RAP1GAP RGS10 RGS19 RGS20 RGS7
Entrez ID		134	2781
HPRD ID		00042	00746
Ensembl ID		ENSG00000163485	ENSG00000128266
Uniprot IDs		B7Z1L9 B7Z379 P30542	P19086 Q8IY73 Q8N652
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process Regulation Of Penile Erection Response To Ammonium Ion Regulation Of CAMP Metabolic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenosine Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Drug Cellular Response To Catecholamine Stimulus Cytosolic Calcium Ion Homeostasis Activation Of Adenylate Cyclase Activity Regulation Of Calcium Ion Transport Platelet Activation Behavior Positive Regulation Of Adenylate Cyclase Activity Regulation Of Ion Transport Cell Surface Receptor Signaling Pathway Locomotory Behavior Regulation Of Secretion Positive Regulation Of Signal Transduction Response To Morphine Cell Activation Muscle System Process Positive Regulation Of Lyase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Lung Alveolus Development Cellular Calcium Ion Homeostasis Regulation Of Phosphorus Metabolic Process Calcium Ion Homeostasis Regulation Of Synaptic Transmission Positive Regulation Of Catalytic Activity Positive Regulation Of CAMP Biosynthetic Process Aging Negative Regulation Of Synaptic Transmission Response To Organonitrogen Compound Regulation Of Synaptic Transmission, Glutamatergic Activation Of MAPKK Activity Positive Regulation Of CAMP Metabolic Process Chemical Homeostasis	Termination Of Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Surface Receptor Signaling Pathway Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Blood Pressure Regulation Of Metabolic Process Histone Dephosphorylation Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Signal Transduction Associative Learning Response To Abiotic Stimulus Cognition Signaling Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission, Dopaminergic Neurological System Process Cell Communication Negative Regulation Of Synaptic Transmission, Glutamatergic Adult Locomotory Behavior Apoptotic Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of Receptor Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dephosphorylation Regulation Of GTPase Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Circadian Rhythm Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Renal Sodium Excretion Regulation Of Cellular Process Learning Regulation Of Anion Transport Regulation Of Excretion
Tagcloud ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1
Tagcloud (Difference) ?		adenosine advance alternatively auto autoregulatory b10 breakdown congenic deaf1 deformed emphasis explain genetics hyperglucagonemia islets nod nonobese orthologs placed polygenic prediabetic prone remarkably roadmap spliced striking studying t1d	adbrk2 alg9 arntl dpysl2 drd3 dusp6 famine gad1 gch1 grin1 grin2b gsk3b hip1r homoeostasis hspa5 impa2 kcnq2 per3 pik3c3 pip5k2a plcg1 rgs4 shuts slc6a3 slc6a4 sybl1 synj1 timeless wfs1
Tagcloud (Intersection) ?