ERCC8 and ERCC6

Number of citations of the paper that reports this interaction (PMID 7664335)
75

Data Source:
HPRD (in vitro)

		ERCC8	ERCC6
Gene Name		excision repair cross-complementation group 8	excision repair cross-complementation group 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein Complex	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex
	Molecular Function	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein Complex Binding	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein Complex Binding Protein N-terminus Binding
	Biological Process	Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination	Response To Superoxide DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Nucleotide Excision Repair Transcription-coupled NER (TC-NER) Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER	Nucleotide Excision Repair RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription-coupled NER (TC-NER) RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CBR1 CSNK2B DDB1 ERCC6 GTF2H2 TOP1 UQCRQ XAB2	15 interactors: BRCA1 CHEK2 ERCC5 ERCC8 GTF2E2 HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A PARP1 POLR2A RNF11 TP53 XAB2 XPA
Entrez ID		1161	2074
HPRD ID		07523	00596
Ensembl ID		ENSG00000049167	ENSG00000225830
Uniprot IDs		B4DGZ9 Q13216	Q03468 Q59FF6 Q8N328
PDB IDs		4A11
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Response To UV Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Cellular Response To DNA Damage Stimulus Response To Light Stimulus Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Radiation Viral Process Subthalamus Development Cellular Response To Stress DNA Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Viral Process Cellular Metabolic Process Phosphorylation UV-damage Excision Repair Vitamin K Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Viral Release From Host Cell Adiponectin-activated Signaling Pathway Activation Of JNKK Activity Wnt Signaling Pathway Endothelial Tube Morphogenesis Pyramidal Neuron Development Pons Development Histone H2A Monoubiquitination Pyramidal Neuron Differentiation Embryonic Cleavage Pyrimidine Dimer Repair G-protein Coupled Receptor Internalization Response To Abiotic Stimulus Thalamus Development Histone H2A Ubiquitination Response To UV-B Cyclooxygenase Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Activin Receptor Signaling Pathway Prostaglandin Biosynthetic Process Regulation Of Viral Release From Host Cell MRNA Processing Hypothalamus Development	DNA Metabolic Process DNA Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To UV Chromatin Assembly Response To Ionizing Radiation Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly Protein Autoubiquitination DNA Packaging Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Response To Stress DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Signal Transduction In Response To DNA Damage DNA Methylation On Cytosine DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Abiotic Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription Chromatin Silencing At RDNA Response To Light Stimulus Replicative Senescence Apoptotic Signaling Pathway Nucleosome Assembly Nucleotide-excision Repair, DNA Damage Removal Nucleosome Organization Negative Regulation Of Biosynthetic Process DNA Damage Checkpoint Response To Oxidative Stress Cellular Macromolecule Catabolic Process Response To X-ray Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing Positive Regulation Of DNA Repair Regulation Of Gene Expression, Epigenetic Chromosome Organization Protein Complex Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process DNA-templated Transcription, Initiation
Tagcloud ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Difference) ?			abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6
Tagcloud (Intersection) ?