ERCC6

Gene Name		excision repair cross-complementation group 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein Complex Binding Protein N-terminus Binding
	Biological Process	Response To Superoxide DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		Nucleotide Excision Repair RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription-coupled NER (TC-NER) RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-protein Interactions		15 interactors: BRCA1 CHEK2 ERCC5 ERCC8 GTF2E2 HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A PARP1 POLR2A RNF11 TP53 XAB2 XPA
Entrez ID		2074
HPRD ID		00596
Ensembl ID		ENSG00000225830
Uniprot IDs		Q03468 Q59FF6 Q8N328
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To UV Chromatin Assembly Response To Ionizing Radiation Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly Protein Autoubiquitination DNA Packaging Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Response To Stress DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Signal Transduction In Response To DNA Damage DNA Methylation On Cytosine DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Abiotic Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription Chromatin Silencing At RDNA Response To Light Stimulus Replicative Senescence Apoptotic Signaling Pathway Nucleosome Assembly Nucleotide-excision Repair, DNA Damage Removal Nucleosome Organization Negative Regulation Of Biosynthetic Process DNA Damage Checkpoint Response To Oxidative Stress Cellular Macromolecule Catabolic Process Response To X-ray Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing Positive Regulation Of DNA Repair Regulation Of Gene Expression, Epigenetic Chromosome Organization Protein Complex Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process DNA-templated Transcription, Initiation
Tagcloud ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6