ERCC6 and GTF2E2

Number of citations of the paper that reports this interaction (PMID 8999876)
63

Data Source:
HPRD (in vitro)

		ERCC6	GTF2E2
Gene Name		excision repair cross-complementation group 6	general transcription factor IIE, polypeptide 2, beta 34kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex	Nucleus Nucleoplasm Transcription Factor TFIIE Complex Cytoplasm
	Molecular Function	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Protein Complex Binding Protein N-terminus Binding	DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Response To Superoxide DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase II Promoter Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth Photoreceptor Cell Maintenance Positive Regulation Of Protein Tyrosine Kinase Activity	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process
Pathways		Nucleotide Excision Repair RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Transcription-coupled NER (TC-NER) RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs
Diseases
GWAS			Cognitive performance ( 20125193)
Protein-Protein Interactions		15 interactors: BRCA1 CHEK2 ERCC5 ERCC8 GTF2E2 HIST1H2AB HIST1H2BB HIST1H3A HIST1H4A PARP1 POLR2A RNF11 TP53 XAB2 XPA	23 interactors: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KLF5 MCC MDM2 MNAT1 NUP62 SND1 SUPT16H TBP XPA
Entrez ID		2074	2961
HPRD ID		00596	01800
Ensembl ID		ENSG00000225830	ENSG00000197265
Uniprot IDs		Q03468 Q59FF6 Q8N328	P29084
PDB IDs			1D8J 1D8K
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process DNA Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Transcription-coupled Nucleotide-excision Repair Cellular Response To Stress Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To UV Chromatin Assembly Response To Ionizing Radiation Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Chromatin Assembly Or Disassembly Protein Autoubiquitination DNA Packaging Intrinsic Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Response To Stress DNA Replication-dependent Nucleosome Assembly DNA Conformation Change Signal Transduction In Response To DNA Damage DNA Methylation On Cytosine DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Abiotic Stimulus DNA Damage Response, Signal Transduction Resulting In Transcription Chromatin Silencing At RDNA Response To Light Stimulus Replicative Senescence Apoptotic Signaling Pathway Nucleosome Assembly Nucleotide-excision Repair, DNA Damage Removal Nucleosome Organization Negative Regulation Of Biosynthetic Process DNA Damage Checkpoint Response To Oxidative Stress Cellular Macromolecule Catabolic Process Response To X-ray Protein-DNA Complex Assembly Transcription Initiation From RNA Polymerase II Promoter Chromatin Silencing Positive Regulation Of DNA Repair Regulation Of Gene Expression, Epigenetic Chromosome Organization Protein Complex Assembly Negative Regulation Of Reactive Oxygen Species Metabolic Process DNA-templated Transcription, Initiation	DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Viral Process Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase I Promoter Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping RNA Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Viral Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Regulation Of RNA Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Metabolic Process Biosynthetic Process DNA Catabolic Process Regulation Of Metabolic Process MRNA Processing Negative Regulation Of Gene Expression
Tagcloud ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6	avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Difference) ?		abca1 adamtsl3 aiming apc crc elac1 epha3 ephb6 excluding exome fbxw7 germline kbiosciences marginal mll3 obscn pkhd1 recessive rs4987622 rs6464211 rs6947538 silico smad4 snps somatic spite strongest syne1 trpv6	avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Intersection) ?