ERCC8 and CBR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ERCC8	CBR1
Gene Name		excision repair cross-complementation group 8	carbonyl reductase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein Complex	Cytosol Vesicle Extracellular Vesicular Exosome
	Molecular Function	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein Complex Binding	Carbonyl Reductase (NADPH) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin-E2 9-reductase Activity
	Biological Process	Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination	Drug Metabolic Process Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Epithelial Cell Differentiation Vitamin K Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Nucleotide Excision Repair Transcription-coupled NER (TC-NER) Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER	Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CBR1 CSNK2B DDB1 ERCC6 GTF2H2 TOP1 UQCRQ XAB2	4 interactors: EGFR ERCC8 UBC VHL
Entrez ID		1161	873
HPRD ID		07523	00267
Ensembl ID		ENSG00000049167	ENSG00000159228
Uniprot IDs		B4DGZ9 Q13216	B4DFK7 P16152
PDB IDs		4A11	1WMA 2PFG 3BHI 3BHJ 3BHM
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Response To UV Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Cellular Response To DNA Damage Stimulus Response To Light Stimulus Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Radiation Viral Process Subthalamus Development Cellular Response To Stress DNA Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Viral Process Cellular Metabolic Process Phosphorylation UV-damage Excision Repair Vitamin K Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Viral Release From Host Cell Adiponectin-activated Signaling Pathway Activation Of JNKK Activity Wnt Signaling Pathway Endothelial Tube Morphogenesis Pyramidal Neuron Development Pons Development Histone H2A Monoubiquitination Pyramidal Neuron Differentiation Embryonic Cleavage Pyrimidine Dimer Repair G-protein Coupled Receptor Internalization Response To Abiotic Stimulus Thalamus Development Histone H2A Ubiquitination Response To UV-B Cyclooxygenase Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Activin Receptor Signaling Pathway Prostaglandin Biosynthetic Process Regulation Of Viral Release From Host Cell MRNA Processing Hypothalamus Development	Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of DNA Repair Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Protein Ubiquitination Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of ERBB Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Positive Regulation Of Cellular Metabolic Process Alkanesulfonate Metabolic Process Regulation Of Response To DNA Damage Stimulus Response To UV Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Negative Regulation Of Programmed Cell Death G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Death ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Protein Polyubiquitination Circadian Rhythm Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Cellular Protein Modification Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Response To Stress Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Activation Of Phospholipase A2 Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition
Tagcloud ?			david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate itsn1 kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?			david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate itsn1 kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?