ERCC8

Gene Name		excision repair cross-complementation group 8
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Gene Ontology Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein Complex
	Molecular Function	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein Complex Binding
	Biological Process	Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination
Pathways		Nucleotide Excision Repair Transcription-coupled NER (TC-NER) Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: CBR1 CSNK2B DDB1 ERCC6 GTF2H2 TOP1 UQCRQ XAB2
Entrez ID		1161
HPRD ID		07523
Ensembl ID		ENSG00000049167
Uniprot IDs		B4DGZ9 Q13216
PDB IDs		4A11
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Response To UV Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Cellular Response To DNA Damage Stimulus Response To Light Stimulus Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Radiation Viral Process Subthalamus Development Cellular Response To Stress DNA Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Viral Process Cellular Metabolic Process Phosphorylation UV-damage Excision Repair Vitamin K Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Viral Release From Host Cell Adiponectin-activated Signaling Pathway Activation Of JNKK Activity Wnt Signaling Pathway Endothelial Tube Morphogenesis Pyramidal Neuron Development Pons Development Histone H2A Monoubiquitination Pyramidal Neuron Differentiation Embryonic Cleavage Pyrimidine Dimer Repair G-protein Coupled Receptor Internalization Response To Abiotic Stimulus Thalamus Development Histone H2A Ubiquitination Response To UV-B Cyclooxygenase Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Activin Receptor Signaling Pathway Prostaglandin Biosynthetic Process Regulation Of Viral Release From Host Cell MRNA Processing Hypothalamus Development
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