TOPBP1 and ATM

Number of citations of the paper that reports this interaction (PMID 11756551)
48

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TOPBP1	ATM
Gene Name		topoisomerase (DNA) II binding protein 1	ATM serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat
Pathways			Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Melanoma ( 21983787) Response to metformin ( 21186350 21845381)
Protein-Protein Interactions		19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17	76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1
Entrez ID		11073	472
HPRD ID		09678	06347
Ensembl ID		ENSG00000163781	ENSG00000149311
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q13315
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process	Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Intersection) ?