TOPBP1 and TCFL5

Number of citations of the paper that reports this interaction (PMID 17006541)
28

Data Source:
HPRD (in vivo)

		TOPBP1	TCFL5
Gene Name		topoisomerase (DNA) II binding protein 1	transcription factor-like 5 (basic helix-loop-helix)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body	Male Germ Cell Nucleus Nucleus
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Dimerization Activity
	Biological Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Spermatogenesis Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17	2 interactors: TOPBP1 USF1
Entrez ID		11073	10732
HPRD ID		09678	05297
Ensembl ID		ENSG00000163781	ENSG00000101190
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q86TP4 Q9UL49
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process	Late Viral Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Transcription By Glucose Response To Radiation Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Response To Abiotic Stimulus Positive Regulation Of Blood Coagulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Coagulation Cellular Response To Nutrient Positive Regulation Of Wound Healing Viral Transcription Regulation Of Blood Coagulation Lipid Homeostasis
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Intersection) ?