TOPBP1 and TOP2B

Number of citations of the paper that reports this interaction (PMID 9461304)
31

Data Source:
HPRD (two hybrid, in vitro)

		TOPBP1	TOP2B
Gene Name		topoisomerase (DNA) II binding protein 1	topoisomerase (DNA) II beta 180kDa
Image
Gene Ontology Annotations	Cellular Component	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing)
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding	Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding DNA Binding, Bending Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change DNA Unwinding Involved In DNA Replication Mitotic Recombination Axonogenesis Forebrain Development Mitotic DNA Integrity Checkpoint
Pathways
Drugs
Diseases
GWAS		Iron status biomarkers ( 19084217)
Protein-Protein Interactions		19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17	14 interactors: CD3E CSNK2B ERG HDAC1 HDAC2 MAPK3 RANBP2 RARA SUMO1 TOP2A TOPBP1 TP53 XPO1 XRCC5
Entrez ID		11073	7155
HPRD ID		09678	00537
Ensembl ID		ENSG00000163781	ENSG00000077097
Uniprot IDs		A0AV47 A7E2X7 Q05BV8 Q92547	Q02880 Q59H80
PDB IDs		1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO	3QX3 4G0U 4G0V 4G0W 4J3N
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process	Cellular Response To Organic Substance Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Nucleus Cell Differentiation Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Heterocycle Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Metabolic Process Response To Drug Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Fungiform Papilla Formation Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Signaling Fungiform Papilla Morphogenesis Regulation Of Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor Biosynthetic Process Response To Growth Factor Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Fungiform Papilla Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised top2a topoisomerases
Tagcloud (Difference) ?		abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised top2a topoisomerases
Tagcloud (Intersection) ?