UBE2L3 and RNF216

Number of citations of the paper that reports this interaction (PMID 15107846)
62

Data Source:
HPRD (in vitro)

		UBE2L3	RNF216
Gene Name		ubiquitin-conjugating enzyme E2L 3	ring finger protein 216
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activator Activity	Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Protein Polyubiquitination Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Proliferation Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 21383967) HDL cholesterol ( 20686565) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 21408207 19838193)
Protein-Protein Interactions		64 interactors: ARIH1 ARIH2 ATXN3 BRCA1 CBL CBLC CCNB1IP1 CUL9 DTX3 FBXO2 FOS HACE1 HERC3 HSPA4 HUWE1 ITCH LIG4 MAPK6 MDM2 MID1 MKRN3 MUL1 NEDD4 NEDD4L NFKBIA NR3C1 PARK2 PJA1 POLR2A PTEN RAD23A RBCK1 RBX1 RELA RNF103 RNF113B RNF125 RNF144A RNF144B RNF19A RNF2 RNF216 SMAD4 SMAD7 SMURF1 SMURF2 STUB1 TRAF6 TRAF7 TRIM21 TRIM28 TRIM39 TRIP12 UBA1 UBA6 UBA7 UBASH3A UBC UBE3A UBE3C UBOX5 UBR5 WWP1 WWP2	11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6
Entrez ID		7332	54476
HPRD ID		04762	15550
Ensembl ID		ENSG00000185651	ENSG00000011275
Uniprot IDs		P68036	A8K8N1 Q9NWF9
PDB IDs		1C4Z 1FBV 3SQV 3SY2
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Polyubiquitination Proteolysis Protein Metabolic Process Catabolic Process Cellular Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Viral Process Regulation Of Protein Catabolic Process Cellular Response To Organic Substance Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Protein K48-linked Ubiquitination Negative Regulation Of Signaling Protein Monoubiquitination Cellular Response To Stress Metabolic Process Protein Autoubiquitination Response To Stress Regulation Of Signal Transduction Intracellular Receptor Signaling Pathway Cellular Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Organic Substance Response To Growth Factor Regulation Of Protein Metabolic Process Regulation Of Type I Interferon Production Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cytokine Production Response To Transforming Growth Factor Beta Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair Positive Regulation Of Protein Catabolic Process	Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity
Tagcloud ?		2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants	amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Difference) ?		2e37a 2e37b cav cav2 channel channels clathrin conjugating conserved dynamin inhibiting interact internalization involves lc1 light map1b mechanism microtubule prevented propose proteasome proteolytic q triggered ubiquitin ubiquitination variants	amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations
Tagcloud (Intersection) ?