RRM2 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 14729598)
25

Data Source:
HPRD (in vitro)

		RRM2	RRM2B
Description		ribonucleotide reductase regulatory subunit M2	ribonucleotide reductase regulatory TP53 inducible subunit M2B
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GO Annotations	Cellular Component	Cytosol Ribonucleoside-diphosphate Reductase Complex	Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Protein Heterotetramerization Oxidation-reduction Process Negative Regulation Of G0 To G1 Transition	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Cladribine Imexon Gallium nitrate motexafin gadolinium GTI 2040	Cladribine
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		8 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B TP53	8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		6241	50484
HPRD ID		01587	05276
Ensembl ID		ENSG00000171848	ENSG00000048392
Uniprot IDs		P31350	Q7LG56
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?
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