RRM2B and RNF41

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		RRM2B	RNF41
Description		ribonucleotide reductase regulatory TP53 inducible subunit M2B	ring finger protein 41
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Ral GTPase Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Proliferation Proteasomal Protein Catabolic Process Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Cladribine
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)	Asthma ( 31619474)
Interacting Genes		8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53	39 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MNAT1 MTNR1A MTNR1B NEUROD4 ORMDL2 PPP1R1A RFC4 RNF166 RRM2B SUOX TBATA TRIM32 TRIM8 TSG101 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		50484	10193
HPRD ID		05276	11520
Ensembl ID		ENSG00000048392	ENSG00000181852
Uniprot IDs		Q7LG56	A0A024RB33 Q9H4P4
PDB IDs		2VUX 3HF1 4DJN	2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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