RRM2 and RRM1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		RRM2	RRM1
Description		ribonucleotide reductase regulatory subunit M2	ribonucleotide reductase catalytic subunit M1
Image
GO Annotations	Cellular Component	Cytosol Ribonucleoside-diphosphate Reductase Complex	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Protein Homodimerization Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Protein Heterotetramerization Oxidation-reduction Process Negative Regulation Of G0 To G1 Transition	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Oxidation-reduction Process Retina Development In Camera-type Eye
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine Imexon Gallium nitrate motexafin gadolinium GTI 2040	Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon gallium maltolate
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Mean corpuscular hemoglobin ( 29403010) Red cell distribution width ( 27863252 28957414)
Interacting Genes		8 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B TP53	8 interacting genes: BMI1 LRIF1 NUP98 PPP1CC RNF2 RRM2 RRM2B YWHAG
Entrez ID		6241	6240
HPRD ID		01587	01588
Ensembl ID		ENSG00000171848	ENSG00000167325
Uniprot IDs		P31350	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI
Enriched GO Terms of Interacting Partners?
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