RRM2B and ORC4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RRM2B	ORC4
Description		ribonucleotide reductase regulatory TP53 inducible subunit M2B	origin recognition complex subunit 4
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs		Cladribine
Diseases		Mitochondrial DNA depletion syndrome (MDS)	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)	Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		50484	5000
HPRD ID		05276	09118
Ensembl ID		ENSG00000048392	ENSG00000115947
Uniprot IDs		Q7LG56	A8K7H4 O43929 Q96B14
PDB IDs		2VUX 3HF1 4DJN	5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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