RRM2B and RRM1

Number of citations of the paper that reports this interaction (PubMedID 11517226)
47

Data Source:
HPRD (in vivo)

		RRM2B	RRM1
Description		ribonucleotide reductase regulatory TP53 inducible subunit M2B	ribonucleotide reductase catalytic subunit M1
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nuclear Envelope Cytosol Ribonucleoside-diphosphate Reductase Complex Cell Projection Neuronal Cell Body
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding ATP Binding Identical Protein Binding Ribonucleoside-diphosphate Reductase Activity Disordered Domain Specific Binding
	Biological Process	Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair Response To Oxidative Stress Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process Response To Amine Nucleobase-containing Small Molecule Interconversion Oxidation-reduction Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Mitotic Cell Cycle Pyrimidine Nucleobase Metabolic Process DNA Replication Male Gonad Development Deoxyribonucleotide Biosynthetic Process Response To Ionizing Radiation Nucleobase-containing Small Molecule Interconversion Cell Proliferation In Forebrain Protein Heterotetramerization Oxidation-reduction Process Retina Development In Camera-type Eye
Pathways		Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Interconversion of nucleotide di- and triphosphates
Drugs		Cladribine	Cladribine Gemcitabine Clofarabine Hydroxyurea Fludarabine Imexon gallium maltolate
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS		Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010)	Mean corpuscular hemoglobin ( 29403010) Red cell distribution width ( 27863252 28957414)
Interacting Genes		8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53	8 interacting genes: BMI1 LRIF1 NUP98 PPP1CC RNF2 RRM2 RRM2B YWHAG
Entrez ID		50484	6240
HPRD ID		05276	01588
Ensembl ID		ENSG00000048392	ENSG00000167325
Uniprot IDs		Q7LG56	B4DXD1 B4E0I8 E9PL69 P23921
PDB IDs		2VUX 3HF1 4DJN	2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y 5TUS 6AUI
Enriched GO Terms of Interacting Partners?
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