PKN1 and HOMER3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		PKN1	HOMER3
Description		protein kinase N1	homer scaffold protein 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Cellular_component Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Junction Dendrite Neuron Projection
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Protein Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Urolithiasis ( 30975718)
Interacting Genes		39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282	31 interacting genes: ABI2 ABI3 APP CEBPB DYNLL2 EAF1 EFHC1 EIF3D FAT1 FRYL GDF15 GRM5 HOMER1 ITPR1 MOS NEBL PAX6 PKN1 POM121 PPP1R18 PRCC PSMA1 PSMA2 PSMC5 RUNX1T1 RYR1 SNRPF SRPK2 TRPC1 USP2 WIPF1
Entrez ID		5585	9454
HPRD ID		03019	07270
Ensembl ID		ENSG00000123143	ENSG00000051128
Uniprot IDs		Q16512	Q9NSC5
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI	2P8V 3CVF
Enriched GO Terms of Interacting Partners?
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