PKN1 and MID1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PKN1	MID1
Description		protein kinase N1	midline 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Spindle Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Protein Binding Microtubule Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Phosphoprotein Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility	Microtubule Cytoskeleton Organization Negative Regulation Of Microtubule Depolymerization Pattern Specification Process Positive Regulation Of Stress-activated MAPK Cascade Protein Localization To Microtubule Interferon-gamma-mediated Signaling Pathway
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Interferon gamma signaling
Drugs
Diseases			Opitz-GBBB syndrome
GWAS		Urolithiasis ( 30975718)
Interacting Genes		39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282	33 interacting genes: BYSL DYRK4 EHHADH FKBP1A GMCL1 HMG20B HTT IGBP1 MEOX1 MID1IP1 MID2 OTUB2 PAX6 PKN1 PPP2CA PPP2CB PTPA SPAG5 STK36 TCEANC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBTD1
Entrez ID		5585	4281
HPRD ID		03019	02047
Ensembl ID		ENSG00000123143	ENSG00000101871
Uniprot IDs		Q16512	A0A024RBV4 A0A087X0X0 A0A087X255 O15344
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI	2DQ5 2FFW 2JUN 5IM8
Enriched GO Terms of Interacting Partners?
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