PKN1 and CDR2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vitro, in vivo)

		PKN1	CDR2
Description		protein kinase N1	cerebellar degeneration related protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Midbody Cleavage Furrow Protein-containing Complex	Cytoplasm
	Molecular Function	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding GTP-Rho Binding Nuclear Receptor Transcription Coactivator Activity Histone Kinase Activity (H3-T11 Specific) Histone Binding Histone Deacetylase Binding Rac GTPase Binding Androgen Receptor Binding	Molecular_function Protein Binding
	Biological Process	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Hyperosmotic Response Signal Transduction Activation Of JUN Kinase Activity Epithelial Cell Migration Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation Histone H3-T11 Phosphorylation Intracellular Signal Transduction Spleen Development Positive Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Motility
Pathways		RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs
Diseases
GWAS		Urolithiasis ( 30975718)
Interacting Genes		39 interacting genes: ACTN1 AKAP9 ARHGAP10 ARHGAP26 BUD23 CASP3 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57L1 GOLGA2 H3C14 HDAC5 HOMER3 KRT15 KRT31 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MTDH NEFH NEFL NEUROD2 PDPK1 PLD1 RHOA SPRR2D SSX2IP TNFRSF1B TRAF1 TRAF2 VIM ZFAND6 ZNF282	43 interacting genes: AMOTL2 ANKRD36BP1 ARNT2 C1orf216 C2CD6 C4orf46 CCDC153 CCHCR1 CDC20 CEP57L1 CHIC2 COX5B EIF4E2 ELOB ENKD1 FAM110A FAM161A FZR1 GMPPA HAUS1 HDAC4 HGS KANSL1 KIFC3 LENG1 LIN37 MORF4L2 MRPL28 NDN NTAQ1 PKN1 RCOR3 RSPH14 SCNM1 SH2D4A SMARCE1 TBC1D22B TCHP TMCC2 TRIM23 TTR TXLNA ZGPAT
Entrez ID		5585	1039
HPRD ID		03019	06681
Ensembl ID		ENSG00000123143	ENSG00000140743
Uniprot IDs		Q16512	Q01850
PDB IDs		1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?
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